GMDTC Chelating Agent Attenuates Cisplatin-Induced Systemic Toxicity without Affecting Antitumor Efficacy.

Cisplatin is a platinum-based chemotherapeutic drug widely used in the treatment of various cancers such as testicular, ovarian, lung, bladder, and cervical cancers. However, its use and the dosage range applied have been limited by severe side effects (e.g.

Mapping dynamic histone modification patterns during arsenic-induced malignant transformation of human bladder cells.

Arsenic is a known potent risk factor for bladder cancer. Increasing evidence suggests that epigenetic alterations, e.g.

Determination of Arbutin in Rat Plasma Using Liquid Chromatography-Tandem Mass Spectrometry: Application to a Pharmacokinetic Study After Oral Administration of the Extract of Vaccinium vitis-idaea.

A rapid and sensitive bioassay based on liquid chromatography-tandem mass spectrometry (LC-MS-MS) has been developed and validated to measure arbutin in rat plasma. Sample preparation of plasma after the addition of indapamide as internal standard (IS) involved solid-phase extraction (SPE) on C18 cartridges. Reversed-phase chromatography using acetonitrile and 0.

[Research on the influence of LED temperature shifts on differential optical absorption spectroscopy for measuring NO2].

Influences of LEDs (without etalon structure and center wavelengths are respectively 370 nm (near-UV), 452 nm (blue) and 660 nm(red)) temperature shifts on differential optical absorption spectroscopy(DOAS) for measuring NO2 were studied. NO2 absorption spectra were formed using LED emitting spectra at 10 degrees C. The measured LED spectra at other temperatures were used as reference spectra of DOAS.

[BTX monitoring nearby main road traffic in Guangzhou].

In order to study the levels of BTX (benzene, toluene, xylene, etc) nearby the main roads of Guangzhou from November 2010 to December 2010 during the Asian Games, BTX and conventional pollutants such as NO2, O3 in the air were monitored by the DOAS system nearby Huangsha Road, which is in the Liwan District of Guangzhou City. The results showed that, during the entire period, BTX showed a high concentration in the evening and the average concentrations of benzene, toluene, p-xylene, m-xylene and phenol were 15.9 microg x m(-3), 61.