Publications by authors named "Nina Zech"

Article Synopsis
  • Many patients report vivid perceptions and experiences while in deep unconscious states, such as during anesthesia or in comas.
  • The most distressing aspect isn't the absence of pain but rather the inability to communicate and feel acknowledged.
  • Despite evidence suggesting that positive communication can have beneficial effects during anesthesia, medical practices regarding the treatment of the unconscious haven't significantly evolved.
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Introduction: The HGSHS:A is one of the most commonly used measures of hypnotic suggestibility. However, this test suffers from low feasibility due to a time requirement exceeding 1 h, and from a questionable representation of the normal population. Recently, a short version of HGSHS-5:G was developed and published, and now the first results are available.

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Article Synopsis
  • Hypnotic trance is described as a unique state of consciousness marked by specific neurophysiological changes, necessitating both subjective and objective measures for accurate assessment, especially in research and clinical settings.
  • A study involving 56 participants utilized monitors for bispectral index (BIS) and cerebral state index (CSI) during a standardized hypnosis test to see how these measures reflect changes in hypnotic susceptibility.
  • Results showed significant drops in BIS and CSI scores upon induction of hypnosis that remained steady during the trance, but there was no difference in physiological responses between participants deemed high or low in suggestibility.
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Article Synopsis
  • * Out of 140 patients, 16 developed POD, and it was more common in men and those with lower mental scores.
  • * The researchers found that music and positive suggestions did not change the occurrence of POD, pain levels, or need for medications after surgery.
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Idiopathic Parkinson's syndrome is associated with the loss of dopaminergic cells. It is defined by the presence of akinesia together with one of the cardinal symptoms: rigor, tremor, or postural instability. As the perioperative management of these patients can be challenging and they have an increased perioperative risk, every anaesthesiologist should know some special features.

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Introduction: In the context of giving risk information for obtaining informed consent, it is not easy to comply with the ethical principle of "primum nihil nocere." Carelessness, ignorance of nocebo effects and a misunderstood striving for legal certainty can lead doctors to comprehensive and brutal risk information. It is known that talking about risks and side effects can even trigger those and result in distress and nonadherence to medication or therapy.

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Postoperative nausea and vomiting (PONV) are one of the most adverse events after general anesthesia, a distressing experience, and pose a risk to the patient. Despite advances in drug prophylaxis and PONV treatment, the incidence remains high and additional non-pharmacological treatments are needed. In this analysis of a recently published double-blind multicenter randomized controlled trial on the efficacy of intraoperative therapeutic suggestions on postoperative opioid dosage, we analyzed the effects of intraoperative therapeutic suggestions on PONV.

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Introduction: The effects of specific suggestions are usually studied by measuring parameters that are directly addressed by these suggestions. We recently proposed the use of a uniform, unrelated, and objective measure like maximal muscle strength that allows comparison of suggestions to avoid nocebo effects and thus to improve communication. Since reduced breathing strength might impair respiration and increase the risk of post-operative pulmonary complications, the aim of the present study was to evaluate the effects of the suggestions on respiratory muscle power.

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Article Synopsis
  • Short-acting anesthetics like propofol allow for quick recovery during awake craniotomy, but they may cause temporary neurocognitive impairment.
  • Neurocognitive tests showed significant drops in word fluency and digit span up to 24 hours post-surgery, particularly impacting older patients, suggesting prolonged effects of anesthesia.
  • In contrast, patients who underwent awake craniotomies without sedation maintained stable cognitive performance, indicating that sedation may play a crucial role in the observed cognitive deficits.
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The Harvard Group Scale of Hypnotic Susceptibility, Form A (HGSHS:A), is commonly used to test hypnotizability. There is still some controversy about what exactly hypnotizability is and whether and how it can be measured, especially by the HGSHS:A. Furthermore, a wider clinical use is limited, requiring a testing time of more than 1 hour.

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Objective: To investigate the effect of therapeutic suggestions played to patients through earphones during surgery on postoperative pain and opioid use.

Design: Blinded randomised controlled study.

Setting: Five tertiary care hospitals in Germany.

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Introduction: The medical environment is full of suggestions that affect patients and their healing. Most of them inadvertently are negative, thus evoking nocebo effects. Recently, we have reported on the effect of such verbal and non-verbal suggestions as well as alternative formulations on maximal muscular arm strength in healthy volunteers.

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Aim was to compare the impact of bedside percutaneous dilational tracheostomy (PDT) and open surgical technique (ST) on intracranial pressure (ICP), pulmonary gas exchange and hemodynamics.We retrospectively analyzed data of 92 neurocritical care patients with invasive ICP monitoring during either PDT (43 patients) or ST (49 patients).Peak ICP levels were higher during PDT (22 [17-38] mm Hg vs 19 [13-27] mm Hg, P = .

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Nocebo effects are not only seen in studies of pharmacology and placebo/nocebo research but also in clinical everyday situations. For generation of objective and quantitative data on the impact of negative communication we have evaluated the immediate effects of common sentences, non-verbal signals and situations in the medical context on muscular performance. In an experimental study, 46 volunteers were tested by dynamometry of the deltoid muscle group to evaluate the maximal muscular strength during arm abduction.

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Article Synopsis
  • Medical interactions can significantly impact a patient's psychological state and recovery, influenced by the use of negative vs. positive language and the quality of the physician-patient relationship.
  • Health care providers should be mindful of the verbal and non-verbal cues patients receive, as negative suggestions (nocebos) can exacerbate issues while positive reinforcement can foster healing.
  • After patient assessments, it's essential to redirect the patient's focus from past negativity to positive experiences or future recovery to mitigate detrimental effects on their health.
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Background: Sedatives and opioids used during deep brain stimulation (DBS) surgery interfere with optimal target localization and add to side effects and risks, and thus should be minimized.

Objective: To retrospectively test the actual need for sedatives and opioids when cranial nerve blocks and specific therapeutic communication are applied.

Methods: In a case series, 64 consecutive patients treated with a strong rapport, constant contact, non-verbal communication and hypnotic suggestions, such as dissociation to a "safe place," reframing of disturbing noises and self-confirmation, were compared to 22 preceding patients under standard general anaesthesia or conscious sedation.

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Background: Transcatheter aortic valve implantation (TAVI) is a minimally invasive procedure used to treat degenerative heart valve disease. The implantation requires a highly specific and interdisciplinary management approach. Currently, TAVI is performed with the patient under local or general anaesthesia.

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Background: Autologous platelet-rich plasma (PRP) can be used either to prevent platelets (PLTs) from lesions during extracorporeal circulation or for wound therapy, when processed into PLT gel. The aim of this study was to evaluate the PLT sequestration abilities of a new-generation autotransfusion device.

Study Design And Methods: In this experimental study the discontinuous, new-generation autotransfusion device XTRA was evaluated using fresh donor blood.

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Background: General anesthesia does not block central nervous processing of auditive information. Therefore, positive suggestions even given during surgery might have the potential to encourage well-being and recovery of patients. Aim of this review was to summarize the evidence on the efficacy of therapeutic suggestions under general anesthesia in adults undergoing surgery compared to an attention control (i.

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Background: Fat in wound blood observed in orthopedic or cardiac surgery might pose a risk for fat embolism during blood salvage. Fat removal was optimized in the washing process.

Study Design And Methods: In an experimental study blood from fresh donations was adjusted to a hematocrit (Hct) of 25% and an admixture of 1.

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Article Synopsis
  • The premedication visit can be challenging for anaesthetists as they must balance providing detailed information with ensuring the patient feels comfortable.
  • Patients may react differently in a hospital setting, impacting their ability to understand complex information.
  • Effective communication strategies can help convey essential anaesthesia information clearly while minimizing unnecessary fear about risks.
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[Nocebo effects with the informed consent].

Anasthesiol Intensivmed Notfallmed Schmerzther

January 2015

Side effects are more frequent and severe, or simply appear by just talking about them. But not the informed consent is to be challenged, rather the form of giving risk information. Nocebo effects mainly originate from induced negative expectations, not from the information itself.

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Background. Inadequate bowel movements might be associated with an increase in intracranial pressure in neurosurgical patients. In this study we investigated the influence of a structured application of laxatives and physical measures following a strict standard operating procedure (SOP) on bowel movement, intracranial pressure (ICP), and length of hospital stay in patients with a serious acute cerebral disorder.

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We report the case of a patient who suffered a serious subarachnoid hemorrhage with a cardialaffection and development of an inverted Tako-Tsubo-cardiomyopathy. To avoid apparent cerebral ischemia due to severe cerebral vasospasm after exhaustion of conservative therapeutic options a temporarily endovascular therapy with continuous intra-arterial application of Nimodipine was necessary. In the overall protracted and complicated course the special challenge were the therapeutic efforts to avoid apparent cerebral ischemia in context to the significant cardial affection.

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