Publications by authors named "Nina Zdouc"
Article Synopsis
- The study investigates the effects of apelin and its receptor APLNR in the context of antiangiogenic therapy for glioblastoma (GBM), particularly focusing on the impact of VEGFA-blocking treatments.
- In proneural GBM, blocking VEGFA or VEGFR2 reduced apelin levels, and interfering with apelin/APLNR signaling significantly decreased tumor vascularization but increased tumor cell invasion.
- Using apelin-F13A, a modified ligand, showed promise in blocking GBM angiogenesis and invasion, suggesting that targeting APLNR alongside VEGFR2 could enhance treatment outcomes and reduce resistance to existing therapies.
