Nail-fold capillary abnormalities are associated with anti-centromere antibody and severity of digital ischaemia.

Objectives: Advances in nail-fold capillaroscopy allow capillary abnormalities to be quantified. Our aim was to investigate, in patients with SSc, the relationships between the degree of nail-fold capillary abnormality and disease subtypes (lcSSc and dcSSc), duration of RP and the presence of (i) severe digital ischaemia (as defined by previous i.v.

Observational study of treatment outcome in early diffuse cutaneous systemic sclerosis.

Objective: Randomized clinical trials in early diffuse cutaneous systemic sclerosis (dcSSc) are challenging. We used an observational approach to estimate the relative effectiveness of different current treatment approaches, capturing entry and outcome data in a standardized way.

Methods: Patients with dcSSc within 3 years of the onset of skin thickening were included.