Publications by authors named "Nina Van Raemdonck"
Although melanoma is notorious for its high degree of heterogeneity and plasticity, the origin and magnitude of cell-state diversity remains poorly understood. Equally, it is unclear whether growth and metastatic dissemination are supported by overlapping or distinct melanoma subpopulations. Here, by combining mouse genetics, single-cell and spatial transcriptomics, lineage tracing and quantitative modelling, we provide evidence of a hierarchical model of tumour growth that mirrors the cellular and molecular logic underlying the cell-fate specification and differentiation of the embryonic neural crest.
View Article and Find Full Text PDFArticle Synopsis
- Scientists discovered that some cancer cells can become resistant to treatment because of special cells that don’t die off, called persister cells or minimal residual disease (MRD).
- In patients with melanoma, they found that a type of stem cell appears during treatment and helps the cancer survive in ways that aren't always genetic.
- By stopping these stem cells from growing, they were able to slow down the return of cancer in experiments, showing that the mix of cells in MRD can change how well cancer treatments work.