Publications by authors named "Nina V Baginskaya"
Article Synopsis
- Opisthorchis felineus, Opisthorchis viverrini, and Clonorchis sinensis are liver flukes linked to human cancer, with O. viverrini and C. sinensis classified as major carcinogens.
- The study involved infecting specific hamsters with these trematodes and analyzing their microbiota using advanced gene sequencing, revealing significant changes in microbial composition.
- All three trematode infections led to an increase in certain harmful bacteria and a decrease in beneficial microbiota, indicating the parasites' profound effect on the host's microbial environment.
The food-borne trematode colonizes bile ducts of the liver of fish-eating mammals including humans. Among chronically infected individuals, this opisthorchiasis involves hepatobiliary problems, including chronic inflammation, periductal fibrosis, biliary intraepithelial neoplasia, and even cholangiocarcinoma. Despite numerous studies at the pathomorphological level, the systemic response and cellular pathogenesis of these disorders are not well studied.
View Article and Find Full Text PDFOpisthorchiasis caused by food-borne trematode Opisthorchis felineus is a substantial public health problem, with 17 million persons infected worldwide. This chronic disease is associated with hepatobiliary inflammation, cholangiocyte dysplasia, cholangiofibrosis, intraepithelial neoplasia, and even cholangiocarcinoma among chronically infected individuals. To provide first insights into the mechanism by which O.
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