Serum concentrations of protease inhibitors as predictors of HIV-related clinical events in patients on antiretroviral therapy.

Serum concentrations of protease inhibitors (PIs) show large interindividual variations. It is not clear what clinical impact these differences in drug concentrations might have. In this study we explored the association between serum concentration of protease inhibitors and HIV-related disease.

Carisoprodol intoxications and serotonergic features.

The symptoms and signs of carisoprodol intoxications do not resemble those caused by its metabolite meprobamate. Meprobamate most probably produces its effects through the GABAergic neurotransmitter system. The signs and symptoms of carisoprodol intoxications, however, are not easily explained by interaction with this neurotransmitter system.

Anion and osmolal gaps in the diagnosis of methanol poisoning: clinical study in 28 patients.

Objective: To evaluate anion and osmolal gaps as diagnostic tools in methanol poisoning.

Design And Setting: Clinical observational study.

Patients And Methods: In a recent methanol outbreak, the initial triage and treatment decisions in 28 patients were based mainly upon the values of the osmolal and anion gaps on admission.