One-end nucleophilic addition of di- and triamines to Pt(IV)-coordinated nitriles as an entry to (amidine)Pt(IV) complexes bearing pendant NH₂-groups.

The reactions of trans-[PtCl₄(RCN)₂] (R= Me, Et, CH₂Ph, Ph) with the diamines and the triamine NH₂{spacer}NH₂ (spacer = CH₂CH₂, CH(Me)CH₂, CH₂CH₂CH₂, CH₂CH₂CH₂CH₂, CH₂CH₂NHCH₂CH₂) in a molar ratio 1 : 2 produce trans-[PtCl₄{NH=C(R)NH{spacer}NH₂}₂] (spacer/R = CH₂CH₂/Et 1, CH₂CHMe/Et 2 (a mixture of regioisomers), CH₂CH₂CH₂/Et 3, CH₂CH₂CH₂CH₂/Et 4, CH₂CH₂/Me 5, CH₂CH₂/CH₂Ph 6, CH₂CH₂/Ph 7, CH₂CH₂NHCH₂CH₂/Et 8) with the monodentately coordinated amidine ligands having the pendant NH₂ groups. The complexes have been characterised by C, H, and N elemental analyses, ¹³C CP-MAS NMR and IR spectroscopy, (TOF)-ESI-MS, and [1·H₂](Pic)₂·EtOH also by X-ray diffraction.

Synthesis, structure and biological activity of nitroxide malonate methanofullerenes.

Two nitroxide methanofullerenes was synthesized for the first time, and their structures and biological activities studied. It was shown by X-ray single crystal analysis that the methanofullerene with two nitroxide groups forms a 1 : 2 inclusion complex with chloroform and has a nearly tetrahedral (diamond-like) arrangement of fullerene-fullerene interactions in the crystal. For the first time, it has been found that malonate nitroxide methanofullerene in combination with the known anticancer drug cyclophosphamide (CPA) shows high antitumor activity against leukemia P-388.