Multidrug-resistant tuberculosis: Treatment and outcomes of 93 patients.

Background: Tuberculosis (TB) remains a leading cause of death worldwide and the emergence of multidrug-resistant TB (MDR TB) poses a threat to its control. There is scanty evidence regarding optimal management of MDR TB. The majority of Canadian cases of MDR TB are diagnosed in Ontario; most are managed by the Tuberculosis Service at West Park Healthcare Centre in Toronto.

Saving Time for Patients with Moderate to Severe COPD: Endurance Test Speed Set Using Usual and Fast Walk Speeds.

: For assessing the effects of interventions on exercise tolerance, the tolerable duration (t) of a high-intensity constant-speed endurance test is recommended. The test intensity is determined by the test speed () which should be individualized to target a t of 3 to 15 minutes. We determined the accuracy of setting the to achieve a targeted t of 3 to 15 minutes using the participant's easily measured and non-fatiguing usual () and fast () walk speeds.

A positron emission tomography study of the 5-HT1A receptor in schizophrenia and during clozapine treatment.

Several post-mortem studies have identified increases of 5-HT1A receptor density in frontal cortical areas in schizophrenic patients, and one has found increases in the cerebellar vermis. Clozapine has moderate affinity at the 5-HT1A receptor, and this may be of therapeutic importance. This positron emission tomography (PET) study attempted to replicate the post-mortem findings in vivo and sought an occupancy effect of clozapine at the 5-HT1A receptor.