Publications by authors named "Nina Lohner"
Article Synopsis
- At critically short telomeres, TERRA RNA-DNA hybrids play a role in promoting homology-directed repair (HDR), which helps delay cellular aging (replicative senescence).
- Even in longer telomeres, transient TERRA RNA-DNA hybrids form, suggesting they may have additional regulatory functions, such as preventing harmful DNA resection when telomeres lose their functionality.
- Experimental evidence using the cdc13-1 allele shows that stabilizing or destabilizing these hybrids influences single-stranded DNA (ssDNA) generation, impacting cell viability while not affecting the overall rate of telomere shortening.
