Publications by authors named "Nina Lindeman"
Article Synopsis
- Complement factor H (FH) is crucial for regulating the alternative complement pathway and has a polymorphism called Y402H linked to age-related macular degeneration (AMD).
- FH from AMD patients with the FH(402H) variant showed significantly less binding to C-reactive protein (CRP) compared to unaffected controls, indicating a functional difference.
- This reduced binding could result in decreased clearance of cellular debris, potentially leading to increased inflammation and contributing to AMD progression.
