Low IQ has become less important as a risk factor for early disability pension. A longitudinal population-based study across two decades among Swedish men.

Background: Low IQ has been shown to be an important risk factor for disability pension (DP) but whether the importance has changed over time remains unclear. It can be hypothesised that IQ has become more important for DP over time in parallel with a more demanding working life. The aim of this study was to investigate the relative risk of low IQ on the risk of DP before age 30 between 1971 and 2006.

Weight status at age 18 influences marriage prospects. A population-based study of Swedish men.

Background: In a longitudinal population-based study of the relationship between body mass index (BMI) in early adulthood and marital status at 40 years of age, obese men were half as likely to be married compared with men of normal weight. Significant associations between obesity and marital status among men in a longitudinal setting are novel findings.

Methods: The study cohort comprised Swedish men born from 1951 to 1961.

Prejudice against obesity among 10-year-olds: a nationwide population-based study.

Aims: Population-based research on children's possible prejudice against thin, obese and average body sizes is scarce. This study examined children's prejudice against various body sizes of both sexes. The effects of sex, body size, place of residence and socio-economic status (SES) on children's prejudice were also investigated.

Obesity in young adulthood is related to social mobility among Swedish men.

Objective: Several studies have shown an inverse relationship between obesity and social status. The aim of this longitudinal study was to disentangle the relationship between BMI and social mobility between generations.

Methods And Procedures: The study population consisted of 752,081 men, born between 1951 and 1965, who were Swedish citizens at conscription examinations.

Blood pressure in young adulthood and later disability pension. A population-based study on 867 672 men from Sweden.

Hypertension is a common chronic condition and can lead to an economic burden for society because of the costs of treatment for high blood pressure and most likely also because of disabilities related to hypertension and its co-morbidities. The aim of this study was to investigate to what extent moderate/severe hypertension in young adulthood increases the risk of becoming a disability pensioner later in life. All Swedish men born 1951 to 1970, who had their systolic blood pressure measured at age 18-19 years in the compulsory military conscription examination were followed from 1990 to 2001 with respect to receiving disability pension.

Obesity in young adulthood and later disability pension: a population-based cohort study of 366,929 Swedish men.

Background: The prevalence of obesity has increased threefold among Swedish men during recent decades. Knowledge from Sweden on how obese men manage in working life and become disability pensioners is sparse. The aim of this nationwide and population-based cohort study was to investigate to what extent body mass index (BMI) in young adulthood predicts later disability pension.

The Swedish Young Male Twins Study: a resource for longitudinal research on risk factors for obesity and cardiovascular diseases.

The Swedish Young Male Twins Study is a population-based longitudinal twin study founded in 1997 through record-linkages of several national registers. Details on pregnancy and birth were obtained from the Swedish Medical Birth Register and used to identify 3566 male twins (1783 pairs) born in Sweden between 1973 and 1979 and resident in Sweden in 1997. A record-linkage was made between the Medical Birth Register and the Military Service Conscription Register for the years 1991 to 1999, providing information on body weight, height, blood pressure, muscle strength, cognitive ability of these twins at age 18 and 19 years.

Physical activity, diet and gene-environment interactions in relation to body mass index and waist circumference: the Swedish young male twins study.

Objective: The aim of the present study was to examine the relationships between genetic susceptibility to obesity, physical activity (PA), dietary fibre, sugar and fat intakes and 4-year changes in body mass index (BMI) and attained waist circumference (WC) in a cohort of 287 monozygotic and 189 dizygotic young adult male twin pairs. Increased knowledge about interactions between genes and environment may provide insight into why some individuals are more prone to obesity than others.

Design: Information about PA, BMI, dietary habits, WC and potential confounders was collected by questionnaire in 1998 and 2002.

Obesity and attained education: cohort study of more than 700,000 Swedish men.

Objective: To study the relationship between BMI at age 18 years and later attained education, with control for intelligence and parental social position.

Research Methods And Procedures: A cohort of 752,283 Swedish men born from 1952 to 1973 were followed in registers with respect to attainment of high education (>or=15 years of education) until December 31, 2001. Intelligence and BMI (kilograms per meter squared) were measured at compulsory military conscription at age 18 years.

Evaluation of anti-tumour effects of oral fenretinide (4-HPR) in rats with human neuroblastoma xenografts.

Neuroblastoma, the most common extracranial solid tumour in children, may undergo spontaneous differentiation or regression, but the majority of metastatic neuroblastomas have poor prognosis despite intensive treatment. Retinoic acid and its analogues regulate growth and differentiation of neuroblastoma cells in vitro, and 13-cis retinoic acid has shown activity against human neuroblastomas in vivo. Fenretinide [N-(4-hydroxyphenyl)retinamide] has been identified as a synthetic retinoid able to induce apoptosis of numerous malignant cell lines in vitro, including neuroblastoma.