Impact of penalizing factor in a block-sequential regularized expectation maximization reconstruction algorithm for F-fluorocholine PET-CT regarding image quality and interpretation.

Background: Recently, the block-sequential regularized expectation maximization (BSREM) reconstruction algorithm was commercially introduced (Q.Clear, GE Healthcare, Milwaukee, WI, USA). However, the combination of noise-penalizing factor (β), acquisition time, and administered activity for optimal image quality has not been established for F-fluorocholine (FCH).