Publications by authors named "Nina Kalyagina"
Comparison of chlorin-e6 detection efficiency by video systems with excitation wavelengths of 405nm and 635nm.
Photodiagnosis Photodyn Ther
September 2023
Article Synopsis
- The study compared two wide field-of-view fluorescence imaging systems with different excitation wavelengths (405 nm and 635 nm) for diagnosing tumors.
- Both systems were tested on tumor phantoms as well as in six patients with basal cell carcinoma and oral mucosa cancer, confirming the ability to define lesion boundaries and fluorescence intensity.
- The 405 nm system outperformed the 635 nm system in distinguishing between tumor and healthy tissue for oral mucosal cancer, indicating greater effectiveness in eliminating background noise and providing consistent fluorescence quantification.
Local targeted "inside-out" hyperthermia of tumors via nanoparticles is able to sensitize tumor cells to chemotherapy, radiation therapy, gene therapy, immunotherapy, or other effects, significantly reducing the duration and intensity of treatment. In this article, new nanomaterials are proposed to be used as anticancer agents: boron-doped nanodiamonds with sizes of about 10 nm synthesized for the first time by the high-temperature high-pressure (HTHP) method. The heating ability of boron-doped nanodiamonds was investigated under different heating conditions in different environments: water, chicken egg white, and MCF-7 breast cancer cells.
View Article and Find Full Text PDFBackground: The study proposes to improve bladder cancer diagnosis by photodynamic diagnosis (PDD) using red-light excitation (632.8 nm) of 5-ALA induced-protoporphyrin IX. Employing 9 patients' bladders, two types of signals were used to improve diagnostic accuracy for malignancy and we also present numerical modeling of the scattering coefficient to provide biological explanation of the results obtained.
View Article and Find Full Text PDFThe purpose of this study is to demonstrate the capabilities of laser spectral and video fluorescence diagnosis used for stomach tumors using 5-ALA photosensitizer. The spectroscopic method is presented with an example of a characteristic fluorescence spectrum from stomach with 5-ALA and quantitative statistics. The laser excitation wavelength was 632.
View Article and Find Full Text PDFBackground: The existence of zones of humoral skin-subskin tissue linkage with internal organs as well as the possibility of targeted administration of preparation into the affected organs were studied.
Methods: An experimental study of preparation and distribution in the bodies of mice was held by both intravenous and lymphotropic methods of administration. By means of detection with a photosensitizer (as a marker), the study was conducted on healthy mice and mice with testicle inflammation.