Publications by authors named "Nina I Uspalenko"
Using a model of Parkinson's disease (PD) induced by the bilateral injection of neurotoxin 6-hydroxydopamine (6-OHDA) into rat brain substantia nigra (SN), we showed uridine to exert a protective effect associated with activation of the mitochondrial ATP-dependent potassium (mitoK-ATP) channel. Injection of 4 µg neurotoxin evoked a 70% decrease in the time the experimental animal spent on the rod in the RotaRod test, an increase in the amount of lipid peroxides in blood serum and cerebral-cortex mitochondria and the rate of reactive oxygen species formation, and a decrease in Ca retention in mitochondria. Herewith, lymphocytes featured an increase in the activity of lactate dehydrogenase, a cytosolic enzyme of glycolysis, without changes in succinate-dehydrogenase activity.
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- Cerebral ischemia affects around 15 million people globally each year, prompting the need for effective prevention and treatment methods in angiology and pharmacology.
- Taxifolin (TAX) has cytoprotective properties, but its effectiveness is limited by poor solubility and difficulty crossing the blood-brain barrier; a water-soluble variant, aqua taxifolin (aqTAX), was studied for its protective effects on brain cells during ischemia-like conditions.
- Findings revealed that aqTAX provided stronger cytoprotection than TAX, inhibiting cell necrosis and apoptosis more effectively, influencing gene expression related to oxidative stress and inflammation, and significantly reducing harmful calcium levels in neurons and astrocytes during ischemia. *