Publications by authors named "Nina I Sharova"
Background: The previously underestimated effects of commensal gut microbiota on the human body are increasingly being investigated using omics. The discovery of active molecules of interaction between the microbiota and the host may be an important step towards elucidating the mechanisms of symbiosis.
Results: Here, we show that in the bloodstream of healthy people, there are over 900 peptides that are fragments of proteins from microorganisms which naturally inhabit human biotopes, including the intestinal microbiota.
A T cell receptor (TCR) consists of α- and β-chains. Accumulating evidence suggests that some TCRs possess chain centricity, i.e.
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- A study involving 5,340 residents of Moscow investigated the relationship between immune responses (antibodies and T cells) to SARS-CoV-2 and the likelihood of COVID-19 infection.* -
- Results showed that individuals with both high T-cell and antibody responses had the lowest risk of infection, while those with only an antibody response also had a strong protective effect.* -
- The findings highlight that antibody responses are more crucial for protection against SARS-CoV-2 compared to T-cell responses, suggesting potential implications for public health policies related to COVID-19.*
Objectives: The immunocytochemical study of the localization of hormones in thymic cells has been performed to clarify possible correlations of their expression with proliferative activity of thymocytes.
Methods: We used commercial antibodies to serotonin, melatonin, somatostatin, glucagon, gastrin, beta-endorphin and histamine, and ABP or BSP kits for visualization of reaction. Computer image analysis was used to find correlations between hormone production and proliferative activity of thymocytes.
The development (and in some part, the functioning) of T lymphocytes occurs providing their contact with epithelial cells. The interaction between T lymphocytes and epithelium is displayed especially clear in the thymus. Chemotactic signals, the source of which are thymic epithelial cells (TEC), play important role in thymus seeding with precursor cells.
View Article and Find Full Text PDFOBJECTIVES: Taking into account the hypothesis that Alzheimer's disease (AD) might be a systemic disease that affects several tissues in the body, the aim of this study was to try to detect the expression of tau-protein in human peripheral blood lymphocytes (PBL) in patients with AD. MATERIAL AND METHODS: Blood samples were obtained from patients with AD (n=16, age 67-98) and from volunteers without psychoneurological pathology (n=10, age 65-78). PBL were isolated on Ficoll-Paque gradient centrifugation.
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