Publications by authors named "Nina Hayduk"
Unlabelled: Chimeric antigen receptor (CAR) T cells are efficacious in patients with B-cell malignancies, while their activity is limited in patients with solid tumors. We developed a novel heterodimeric TCR-like CAR (TCAR) designed to achieve optimal chain pairing and integration into the T-cell CD3 signaling complex. The TCAR mediated high antigen sensitivity and potent antigen-specific T-cell effector functions in short-term assays.
View Article and Find Full Text PDFObjective: The aim: The aim of the research was to investigate the issue of emotional health in the context of mental health of students, in particular, the emotional instability as a students' personal quality with regard to cognitive and empathic components.
Patients And Methods: Materials and methods: In a comparative analysis of the study, 104 3rd-year students of the Faculty of Management and Media Communications of the Ukrainian Academy of Printing, were divided into two groups on the basis of gender (group №1 - females; group №2 - males). In the study, undertaken in 2019-2020, two questionnaires, namely "Problems of Emotional Health" and "Assessment of Empathic Compassion", drawn up by a team of authors, were used.
Article Synopsis
- CAR-T cells are effective against B cell malignancies but struggle with solid tumors due to limited targets and poor persistence.
- The researchers propose using claudin 6 (CLDN6) as a target for solid tumors and develop a nanoparticle RNA vaccine to enhance CAR-T cell stimulation.
- This strategy improves CAR
Article Synopsis
- The study investigates how leukemic cells find refuge in the bone marrow and the role of specific adhesion molecules, CD44 and E-selectin, in chronic myeloid leukemia (CML).
- Researchers hypothesized that inhibiting the adhesion of CML-initiating cells to the bone marrow's E-selectin could enhance the effectiveness of imatinib treatment, and found that combining the E-selectin inhibitor GMI-1271 with imatinib improved survival in mice by reducing leukemic cell interactions with the bone marrow.
- The findings suggest that targeting specific molecular pathways, such as the modulation of adhesion molecules like CD44 and the phosphorylation of SCL/TAL1, could lead to better treatment strategies for CML in humans
Targeting mRNA to eukaryotic cells is an emerging technology for basic research and provides broad applications in cancer immunotherapy, vaccine development, protein replacement, and in vivo genome editing. Although a plethora of nanoparticles for efficient mRNA delivery exists, in vivo mRNA targeting to specific organs, tissue compartments, and cells remains a major challenge. For this reason, methods for reporting the in vivo targeting specificity of different mRNA nanoparticle formats will be crucial.
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