Publications by authors named "Nina Haunstrup Jensen"
J Immunother Cancer
October 2024
Article Synopsis
- Immune checkpoint inhibitors (ICI) have greatly improved treatment for metastatic malignant melanoma (MM), but not all patients respond, leading researchers to explore biomarkers like galectin-3 (Gal-3) for predicting treatment response.
- The study investigated how Gal-3 interacts with programmed cell death protein 1 (PD-1) and the drug pembrolizumab using advanced techniques like surface plasmon resonance (SPR) and cryogenic electron microscopy (cryo-EM).
- Results showed that Gal-3 can block the binding of PD-1 to pembrolizumab, reducing T cell activity and suggesting that high Gal-3 levels in plasma are linked to better survival outcomes, while high Gal-3 in tumors correlates with
