Bioinformatics tools for the sequence complexity estimates.

We review current methods and bioinformatics tools for the text complexity estimates (information and entropy measures). The search DNA regions with extreme statistical characteristics such as low complexity regions are important for biophysical models of chromosome function and gene transcription regulation in genome scale. We discuss the complexity profiling for segmentation and delineation of genome sequences, search for genome repeats and transposable elements, and applications to next-generation sequencing reads.

Biophysics education section and computational training discussion at VII Congress of Russian Biophysicists.

We present commentaries on the section "Biophysical education" of the VII Congress of Russian Biophysicists. Presentations are briefly introduced along with the current problems of biophysical education and the educational approach development. We discuss educational course on bioinformatics based on the integration of online databases and the usage of internet platforms for functional annotation of genes and proteins.

Medical Genetics, Genomics and Bioinformatics-2022.

The analysis of molecular mechanisms of disease progression challenges the development of bioinformatics tools and omics data integration [...

Statistical estimates of multiple transcription factors binding in the model plant genomes based on ChIP-seq data.

The development of high-throughput genomic sequencing coupled with chromatin immunoprecipitation technologies allows studying the binding sites of the protein transcription factors (TF) in the genome scale. The growth of data volume on the experimentally determined binding sites raises qualitatively new problems for the analysis of gene expression regulation, prediction of transcription factors target genes, and regulatory gene networks reconstruction. Genome regulation remains an insufficiently studied though plants have complex molecular regulatory mechanisms of gene expression and response to environmental stresses.

Glioblastoma gene network reconstruction and ontology analysis by online bioinformatics tools.

Glioblastoma is the most aggressive type of brain tumors resistant to a number of antitumor drugs. The problem of therapy and drug treatment course is complicated by extremely high heterogeneity in the benign cell populations, the random arrangement of tumor cells, and polymorphism of their nuclei. The pathogenesis of gliomas needs to be studied using modern cellular technologies, genome- and transcriptome-wide technologies of high-throughput sequencing, analysis of gene expression on microarrays, and methods of modern bioinformatics to find new therapy targets.