Superoxide Dismutase 1 Nanozyme for Treatment of Eye Inflammation.

Use of antioxidants to mitigate oxidative stress during ocular inflammatory diseases has shown therapeutic potential. This work examines a nanoscale therapeutic modality for the eye on the base of antioxidant enzyme, superoxide dismutase 1 (SOD1), termed "nanozyme." The nanozyme is produced by electrostatic coupling of the SOD1 with a cationic block copolymer, poly(L-lysine)-poly(ethyleneglycol), followed by covalent cross-linking of the complexes with 3,3'-dithiobis(sulfosuccinimidylpropionate) sodium salt.

Image analysis and glare sensitivity in human age-related cataracts.

Background: A new glare disability test and a diagnostic instrument, the Halometer, were proposed for measuring intraocular light scattering in the presence of human cataracts. The objectives of this work were to introduce new methods of computer-generated analysis of lens images and a glare disability test to validate the use of two new tests to measure the severity of cataract and to document and quantify changes in lens clarity at diagnosis in a group of patients with age-related cataract with minimal to advanced opacities.

Methods: The authors followed 28 patients (46 eyes) with an average age of 66.

Efficacy of N-acetylcarnosine in the treatment of cataracts.

Purpose: To evaluate the effects of 1% N-acetylcarnosine (NAC) solution on lens clarity over 6 and 24 months in patients with cataracts.

Trial Design: Randomised, placebo-controlled study.

Participants: 49 subjects (76 affected eyes) with an average age of 65.