Publications by authors named "Nina Eide Hasselberg"
Background: The electrophysiological mechanism connecting mitral valve prolapse (MVP), premature ventricular complexes and life-threatening ventricular arrhythmia is unknown. A common hypothesis is that stretch activated channels (SACs) play a significant role. SACs can trigger depolarizations or shorten repolarization times in response to myocardial stretch.
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- This study investigated severe cardiac events in children with arrhythmogenic right ventricular cardiomyopathy (ARVC) and its occurrence in their genetic relatives.
- Among 62 pediatric ARVC patients, 32% received a definite ARVC diagnosis, with a significant portion having childhood-onset cases, leading to a high incidence of severe cardiac events, especially in younger patients.
- The findings highlight the importance of early screening for ARVC in families, as the penetrance in relatives increased over time, indicating a need for intervention at a younger age than what is currently advised.
Aims: Lamin A/C (LMNA) mutations cause familial dilated cardiomyopathy (DCM) with frequent conduction blocks and arrhythmias. We explored the prevalence, cardiac penetrance, and expressivity of LMNA mutations among familial DCM in Norway. Furthermore, we explored the risk factors and the outcomes in LMNA patients.
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