Advanced monitoring and control of pharmaceutical production processes with by using Raman spectroscopy and multivariate calibration methods.

This contribution includes an investigation of the applicability of Raman spectroscopy as a PAT analyzer in cyclic production processes of a potential Malaria vaccine with . In a feasibility study, Partial Least Squares Regression (PLSR) models were created off-line for cell density and concentrations of glycerol, methanol, ammonia and total secreted protein. Relative cross validation errors RMSE range from 2.