Angiolymphoid Hyperplasia with Eosinophilia Successfully Treated with Cryotherapy.

Background: Angiolymphoid hyperplasia with eosinophilia is an uncommon, benign, vasoproliferative cutaneous neoplasm with uncertain origin. It preferably affects middle-aged adults, manifesting as plum-colored pruritic papules, nodules and plaques, which can persist indefinitely, relapsing over time. Different response/resistance to various therapeutic modalities and frequent recurrences impose a great therapeutic dilemma.

Giant Bowen's Disease on the Face: Case Report and Review of the Literature.

Background: Giant Bowen's disease is a rare and unusual clinical manifestation. Presenting as extensive scaly erythematous patch or plaque, it gives rise to a wide spectrum of dermatological differential diagnoses.

Case Presentation: We report a patient with giant Bowen's disease on the face that was successfully treated with topical 5 % imiquimod.

Necrolytic Migratory Erythema: Complete Healing after Surgical Removal of Pancreatic Carcinoma.

Necrolytic migratory erythema is considered an obligatory cutaneous paraneoplastic sign associated with glucagonoma. Glucagonoma syndrome is defined by the presence of an alpha-cell secreting tumor of the pancreas, elevated levels of glucagon, and a characteristic rash called necrolytic migratory erythema. Although necrolytic migratory erythema is a specific finding in glucagonoma syndrome, it may occur in other settings, unassociated with an alpha-cell pancreatic tumor (pseudoglucagonoma syndrome).

PUVA-induced Bullous Pemphigoid in Psoriasis.

The association between psoriasis vulgaris and bullous pemphigoid is due to the still unclear autoimmune process. The common disease site is the dermo-epidermal junction or basal membrane zone (BMZ), with specific alterations for both diseases. Photochemotherapy (PUVA) is one of the therapeutic modalities for psoriasis and can trigger production of autoantibodies against antigens in the BMZ in patients with subclinical bullous pemphigoid.

Successful management of ustekinumab-induced pustular psoriasis without therapy discontinuation.

We present a 34-year-old female patient with methotrexate unresponsive longstanding plaque psoriasis who developed pustular psoriasis ten weeks after initiation of ustekinumab therapy. Given the lack of other side effects and the rapid initial response of the underlying plaque psoriasis, we opted against discontinuing ustekinumab therapy. Topical corticosteroids were added for the management of pustular lesions on initial presentation.

Epidemiology of pemphigus in Macedonia: a 15-year retrospective study (1990-2004).

Background: Pemphigus is an autoimmune blistering skin disease mediated by auto-antibodies directed against desmoglein proteins. There are only a few epidemiological studies on pemphigus. Our objective was to determine the epidemiological features of pemphigus in Macedonia, and to compare the results with those reported elsewhere.

Frequency of delayed-type hypersensitivity to contact allergens in palmo-plantar psoriasis.

Unlabelled: Psoriasis is a common, chronic, genetically determined, T-cell-mediated inflammatory dermatosis. The aim of this study is to determine the frequency of delayed-type hypersensitivity to contact allergens in palmo-plantar psoriasis and their importance in provoking and/or perpetuating the same.

Materials And Methods: 101 patients with different clinical forms of psoriasis were included in our study.

Management of guttate and generalized psoriasis vulgaris: prospective randomized study.

Aim: To assess the efficacy of betamethasone dipropionate 0.05% cream plus ultraviolet B (UVB) radiation with and without additional penicillin therapy in the treatment of guttate psoriasis, and to compare the efficacies of oral psoralen plus ultraviolet A (PUVA) therapy and systemic retinoids therapy for treatment of generalized psoriasis.

Methods: Sixty patients with guttate (n = 20) and generalized psoriasis vulgaris (n = 40) of various intensity and duration treated at the Department of Dermatology, Medical School in Skopje, from February 2000 to January 2002, were included in this prospective, open-label, randomized, parallel group study.