Structural and Biological Investigations for a Series of N-5 Substituted Pyrrolo[3,2-]pyrimidines as Potential Anti-Cancer Therapeutics.

Pyrrolo[3,2-]pyrimidines have been studied for many years as potential lead compounds for the development of antiproliferative agents. Much of the focus has been on modifications to the pyrimidine ring, with enzymatic recognition often modulated by C2 and C4 substituents. In contrast, this work focuses on the N5 of the pyrrole ring by means of a series of novel N5-substituted pyrrolo[3,2-]pyrimidines.