Publications by authors named "Nina C C J Kokke"
Article Synopsis
- Myopia (nearsightedness) is a common eye condition caused by a mismatch between how the eye focuses light and its length.
- This study looked at how different types of light (like UVA, violet, cyan, green/yellow, red, and white) affect the eye growth of zebrafish.
- Findings suggest that exposure to cyan or red light reduces eye length, indicating that light conditions could be a potential strategy to control myopia.
Article Synopsis
- Genome-wide association studies (GWAS) have identified genetic factors related to refractive errors like myopia, but the functional roles of these genes are not well-explored.
- Researchers focused on nine candidate genes and used CRISPR/Cas9 to create knock-out zebrafish to study changes in axial length and refractive status.
- They found that three genes (LAMA2, LRRC4C, KCNQ5) were linked to myopia development, as their knock-out led to increased axial length and myopic shift, highlighting their potential role in the condition.
Transl Vis Sci Technol
March 2022
Article Synopsis
- The study aims to create assays for testing genes related to ocular diseases in zebrafish, particularly focusing on refractive error.
- The researchers developed a comprehensive pipeline to measure key ocular factors like biometry, refractive status, intraocular pressure, and visual response, and validated it using zebrafish mutants of two specific genes (PRSS56 and FBN1).
- Results demonstrated significant ocular changes in the zebrafish mutants, supporting the pipeline's effectiveness and the use of zebrafish as a model for studying human ocular diseases.
