New type of filaments for improved accuracy of multiple sulfur isotope analyses by electron-impact gas-source mass spectrometry.

Rationale: The analysis of the three sulfur stable isotope ratios (S/S, S/S, S/S) is routinely performed by gas-source isotope ratio mass spectrometry (IRMS) on the SF gaseous molecule, collecting SF ions at m/z ~ 127, 128, 129 and 131. High precision and accuracy are commonly achieved owing to a lack of correction because fluorine has only one isotope and the inert nature of the SF molecule. The analysis of the S/S ratio is, however, complicated by the low abundance of S (~0.

Determination of the triple oxygen and carbon isotopic composition of CO from atomic ion fragments formed in the ion source of the 253 Ultra high-resolution isotope ratio mass spectrometer.

Rationale: Determination of δ O values directly from CO with traditional gas source isotope ratio mass spectrometry is not possible due to isobaric interference of C O O on C O O. The methods developed so far use either chemical conversion or isotope equilibration to determine the δ O value of CO . In addition, δ C measurements require correction for the interference from C O O on C O O since it is not possible to resolve the two isotopologues.

Herpes simplex virus immediate-early protein ICP0 is targeted by SIAH-1 for proteasomal degradation.

Herpes simplex virus (HSV) immediate-early protein ICP0 is a transcriptional activator with E3 ubiquitin ligase activity that induces the degradation of ND10 proteins, including the promyelocytic leukemia protein (PML) and Sp100. Moreover, ICP0 has a role in the derepression of viral genomes and in the modulation of the host interferon response to virus infection. Here, we report that ICP0 interacts with SIAH-1, a cellular E3 ubiquitin ligase that is involved in multiple cellular pathways and is itself capable of mediating PML degradation.

Description of an aerodynamic levitation apparatus with applications in Earth sciences.

Background: In aerodynamic levitation, solids and liquids are floated in a vertical gas stream. In combination with CO2-laser heating, containerless melting at high temperature of oxides and silicates is possible. We apply aerodynamic levitation to bulk rocks in preparation for microchemical analyses, and for evaporation and reduction experiments.

Subjective sleep quality in noncomplaining elderly subjects: results of a follow-up study.

The present study aims at investigating subjective sleep quality and its stability in a sample of not complaining elderly subjects (60 to 85 years). Sleep quality was assessed by means of the Pittsburgh Sleep Quality Index (PSQI). At baseline 91 subjects (46 males and 45 females; age: 66.