Publications by authors named "Nina A Sibbesen"
Article Synopsis
- * Researchers found that malignant T cells show lower levels of the tumor suppressor microRNA, miR-22, and that STAT5 can bind to the gene controlling miR-22.
- * Inhibiting Jak3 and its effectors, along with treatment using curcumin or HDAC inhibitors, can increase miR-22 levels, suggesting that miR-22 may play a role in suppressing CTCL progression by targeting various oncogenes.
Skin lesions from mycosis fungoides (MF) patients display an increased expression of interleukin-15 (IL-15), IL-17F, and other cytokines implicated in inflammation and malignant cell proliferation in cutaneous T-cell lymphoma (CTCL). In the leukemic variant of CTCL, Sézary syndrome (SS), IL-2 and IL-15 trigger activation of the Jak-3/STAT3 pathway and transcription of IL17A gene, whereas it is unknown what causes IL-15 expression, Jak3/STAT3 activation, and production of IL-17F in MF. Here, we studied the expression and regulation of IL-15 and its relation to IL-17F in MF cell lines and skin lesions from 60 MF patients.
View Article and Find Full Text PDF