Publications by authors named "Nin Guan"
Article Synopsis
- Most lung cancer patients, especially those with EGFR mutations, develop resistance to treatment drugs like osimertinib and gefitinib, often leading to relapse.*
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- Genome-wide CRISPR screenings pinpointed key resistance pathways, revealing that regulation of the Hippo pathway is a significant factor in this drug resistance among cancer cells.*
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- Targeting both the Hippo pathway and EGFR together shows promise as a new treatment approach for EGFR mutant lung cancer, potentially improving outcomes for patients.*
Mol Cancer Ther
November 2015
Article Synopsis
- Exogenous expression of AKT1(E17K) in breast epithelial cells leads to increased AKT activation, colony formation, and tumor growth in mice, which can be inhibited by AKT inhibitors MK-2206 and AZD5363.
- Clinical studies indicate that AZD5363 shows promise in treating breast and ovarian cancers with AKT1(E17K) mutations, but may require combination therapies for effective treatment in tumors with additional oncogenic mutations.
