Publications by authors named "Nimshitha P Abdul Manaph"
Unlabelled: Abnormal cytokine levels in circulating blood have been repeatedly reported in autism; however, the underlying cause remains unclear. This systematic review aimed to investigate cytokine levels in peripheral blood compartments and identify their potential immune cellular sources in subjects with autism through comparison with controls. We conducted an electronic database search (PubMed, Scopus, ProQuest Central, Ovid, SAGE Journals, and Wiley Online Library) from inception (no time limits) to July 9, 2020, and identified 75 relevant articles.
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- Generating neural stem cells (NSC) from somatic cells using transcription factors has risks, including tumor formation and genomic instability, making clinical use challenging.
- A new method using small molecules instead of viral vectors has been developed, efficiently transforming mouse fibroblasts into NSC-like cells (SMINS) that mimic the properties of natural NSC.
- SMINS cells can differentiate into various types of neural cells and, by avoiding genome alteration, present a safer option for potential clinical applications in treating human diseases.