Stimulus characteristics of the mouse's visual field differ above and below the skyline. Here, we show for the first time that retinal ganglion cells (RGCs), the output neurons of the retina, gradually change their functional properties along the ventral-dorsal axis to allow better representation of the different stimulus characteristics. We conducted two-photon targeted recordings of transient-Offα-RGCs and found that they gradually became more sustained along the ventral-dorsal axis, revealing >5-fold-longer duration responses in the dorsal retina.
View Article and Find Full Text PDFParkinsonism Relat Disord
November 2017
Background: Mind Wandering (MW) refers to the process of disengaging from the immediate external environment and participating in internally driven mentation. This process has been suggested to be supported by a distributed set of brain regions, collectively referred to as the Default Mode Network (DMN). Recently, reduced recruitment and connectivity of the DMN has been described in Parkinson's disease (PD) patients compared to healthy controls.
View Article and Find Full Text PDFAn inherent limitation of human visual system research stems from its reliance on highly controlled laboratory conditions. Visual processing in the real world differs substantially from such controlled conditions. In particular, during natural vision, we continuously sample the dynamic environment by variable eye movements that lead to inherent instability of the optical image.
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