Publications by authors named "Nimit Shah"

Objective: To describe volunteer firefighters' perspectives on how firefighter- and fire department-level factors influence their physical activity and fitness.

Methods: Firefighters (n = 28) were interviewed, stratified by their years of firefighting, using an interview guide. Thematic analysis and systematic coding were used to analyze the interview transcripts.

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  • The Rutgers School of Public Health created a project to improve diversity, equity, and inclusion (DEI) in their teaching.
  • They developed a special tool to help teachers reflect on how well their courses promote DEI, using feedback from professors, students, and staff.
  • The project offers a detailed 6-step plan to help schools develop better DEI programs and adapt to different challenges they face.
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  • Visudyne is the only approved nanomedicine for photodynamic therapy, using a stable form of the drug BPD conjugated to a specific lysophospholipid, BPD-PC, which effectively targets cancer cells.
  • The study compares BPD-PC incorporated in solid lipid nanoparticles (similar to the Spikevax vaccine) against traditional liposomal formulations, revealing that the solid lipid nanoparticles generate more singlet oxygen and maintain better stability by significantly reducing the leaching of BPD-PC.
  • Despite different chemical properties, both formulations showed similar cellular uptake and phototoxicity against pancreatic cancer cells, but the solid lipid nanoparticles enhanced immunogenic cell death more effectively, suggesting potential for improved cancer therapies.
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  • Cetuximab (Cet)-IRDye800CW is an antibody-IRDye800CW conjugate that shows promise for identifying tumor margins during fluorescence-guided surgery and is being explored for post-surgery treatment of residual cancer cells using photodynamic therapy (PDT).
  • The study highlights that increasing the number of dye molecules attached to the antibody from 2 to 11 enhances the effectiveness of Cet-IRDye800CW, enabling it to produce reactive species that can harm cancer cells, inducing approximately 90% phototoxicity in FaDu head and neck cancer cells.
  • Antibody-targeted PDT with the higher dye payload offers improved cancer cell specificity and reduced toxicity in non-cancerous
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Background: Although firefighters have increased risk for colon and prostate cancer, limited information exists on screening practices for these cancers in volunteer firefighters who compose two-thirds of the US fire service. We estimated the prevalence of colon and prostate cancer screening among volunteer firefighters using eligibility criteria from 4 evidence-based screening recommendations and evaluated factors influencing screening.

Methods: We evaluated colon (n = 569) and prostate (n = 498) cancer screening prevalence in a sample of US volunteer firefighters using eligibility criteria from the US Preventive Services Taskforce (USPSTF), National Fire Protection Association, American Cancer Society, and National Comprehensive Cancer Network.

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Desmoplasia in pancreatic ductal adenocarcinoma (PDAC) limits the penetration and efficacy of therapies. It has been previously shown that photodynamic priming (PDP) using EGFR targeted photoactivable multi-inhibitor liposomes remediates desmoplasia in PDAC and doubles overall survival. Here, bifunctional PD-L1 immune checkpoint targeted photoactivable liposomes (iTPALs) that mediate both PDP and PD-L1 blockade are presented.

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Background: Firefighters have a higher risk of melanoma incidence and mortality compared to the general population. In the United States (US), the National Fire Protection Association recommends all firefighters receive annual skin cancer screening through visual skin examination by a clinician. However, there is limited information on skin cancer screening practices among volunteer firefighters who comprise two-thirds of the US fire service.

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Polarized light interactions with biological tissues can reveal information regarding tissue structure, while spectral characteristics are closely related to tissue composition. An integration of both modalities in a compact system could better assist tissue assessment. This study aims to develop a polarized hyperspectral imaging (PHSI) system that fulfills both linearly and circularly polarized hyperspectral imaging for and applications.

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  • Desmoplasia, prevalent in pancreatic ductal adenocarcinoma (PDAC), creates barriers to treatment and contributes to a low 5-year survival rate of only 3%.
  • The study introduces targeted photoactivable multi-inhibitor liposomes (TPMILs) that effectively combine photodynamic therapy and chemotherapy to combat PDAC while also reducing desmoplasia.
  • TPMILs show a 90% reduction in tumor growth and significantly improve survival rates, making them a promising approach for patients with this aggressive cancer.
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  • Specialized photonanomedicines (PNMs) have evolved to be activated by energy sources like near-infrared radiation, high-energy particles, and acoustic waves, enabling deeper tissue penetration than visible light.
  • These PNMs utilize both direct activation (e.g., upconversion and scintillation) and indirect activation methods (e.g., sonoluminescence and Cerenkov radiation) to enhance deep-tissue cancer treatment.
  • The review assesses current preclinical research on deep-tissue activation mechanisms and discusses the potential for clinical application, highlighting ways to adapt existing clinical equipment for effective photodynamic therapy.
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The use of microcatheters as a coronary interventional tool for a therapeutic approach to complex coronary interventions like bifurcation lesions, ostial location, tortuous anatomy, angled takeoffs, coronary calcification, and chronic total occlusion (CTO) percutaneous coronary intervention (PCI) is growing among cardiologists across the country. During the treatment of such complex lesions, microcatheters play an essential part of the tool kit with both single-lumen and double-lumen microcatheters (DLMs) having their specific niche areas. The selection of microcatheters involves a detailed understanding of the microcatheter specification, lesion anatomy, lesion location, vessel tortuosity and trajectory, and crossing techniques.

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The emergence of biomimetic nanotechnology has seen an exponential rise over the past decade with applications in regenerative medicine, immunotherapy and drug delivery. In the context of nanomedicines activated by near infrared (NIR) photodynamic processes (photonanomedicines; PNMs), biomimetic nanotechnology is pushing the boundaries of activatable tumor targeted nanoscale drug delivery systems. This review discusses how, by harnessing a unique collective of biological processes critical to targeting of solid tumors, biomimetic PNMs (bPNMs) can impart tumor cell specific and tumor selective photodynamic therapy-based combination regimens.

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Background: Per-and polyfluoroalkyl substances (PFAS), are ubiquitous pollutants associated with adverse health outcomes. High PFAS levels have been demonstrated among career firefighters; less is known about PFAS levels among volunteer firefighters who comprise two-thirds of US firefighters.

Methods: Volunteer fire department members completed a survey and provided blood samples.

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Objective: There is a growing literature on the risk of chronic disease among firefighters, including cardiovascular disease (CVD) and cancer. However there is little information on firefighter's perception thereof.

Methods: Firefighters attending a union convention in New Jersey completed a survey with four domains: firefighting experience; perceived additional risk for chronic diseases (six-point Likert scale); cancer screening history; demographics, and risk behaviors.

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Objective: To characterize the diet of volunteer firefighters compared with the United States recommended dietary intake.

Methods: A survey was administered to members of volunteer fire department which collected information on demographics, behavioral risks, fire service history, and dietary intake using the Dietary Screener Questionnaire. Dietary intake was compared with US recommendations; associations between dietary intake and years of firefighting, were assessed using bi- and multivariate analysis.

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Background: New Jersey (NJ) Safe Schools Program, primarily funded by the NJ Department of Education, has aims concerning safety and health including helping to alleviate harassment, intimidation, and bullying (HIB) in secondary school because HIB can affect learning. We evaluated officially reported adolescent HIB total incidents and estimated rates in NJ public city and county school districts for the 2011-2016 school years.

Methods: A cross-sectional observational study using population-based state-reported public data.

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Introduction: Adolescents engaging in school-sponsored work experiences may be at risk of injury due to factors such as inexperience. This article examines trends in 20 years of reported injuries among New Jersey (NJ) adolescents engaging in school-sponsored work experiences, and compares a transition from paper to online reporting format.

Methods: New Jersey requires reporting of injuries occurring during school-sponsored work experiences to the NJ Department of Education.

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Sustainable Jersey for Schools (SJS) includes free and voluntary certification for New Jersey (NJ) public K-12 districts (SD) and schools. SJS promotes increased awareness for waste and greenhouse gas emissions reductions via energy efficiency and conservation measures; environmental education; equity; etc. SD first register with SJS; school(s) then register and pursue one of two current certification levels, bronze or silver.

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Background: There is an increasing concern over adolescent concussions in sports due to risks of long-term negative effects. This study analyzed data over three school years on reported concussion incidence rates by season, high school grade levels and gender, and reported symptoms by school nurses versus athletic trainers, from New Jersey student-athlete concussion data available from an online school-based surveillance system.

Methods: School nurses and athletic trainers reported 300 concussions within five days from when each occurred over three school years, 2015-2018, in team sports and physical education in New Jersey high schools.

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  • Researchers developed a virtual audit tool to assess pedestrian injury risk at intersections using Google Street View, which saves time and costs associated with in-person inspections.
  • The tool, consisting of 38 items, was tested on intersections near 26 schools in NYC for reliability, with significant inter-rater agreement found.
  • Key reliable factors included pedestrian signals, overhead structures, and intersection complexity, indicating that virtual assessments can effectively contribute to pedestrian safety strategies.
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Very late stent recoil is a rare albeit recognized phenomenon leading to subsequent in-stent restenosis. Angiography alone may not be adequate in making the diagnosis, and intravascular imaging with optical coherence tomography (OCT) is far superior in confirming the diagnosis and guiding subsequent management. We describe a case with interesting coronary angiogram and OCT images demonstrating very rare diagnosis of the late stent collapse.

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  • The STOP study investigated the impact of routine postdilatation (PD) guided by intravascular ultrasound (IVUS) on drug-eluting stent (DES) deployment to improve clinical outcomes linked to low stent cross-sectional area (CSA).
  • It included 48 patients and found that only 21% of DESs met optimal deployment criteria after implantation, while 54% met the criteria after PD.
  • Ultimately, 81% of cases achieved optimal CSA after additional IVUS-guided PD, suggesting that optimizing DES deployment could enhance long-term clinical results, although further randomized studies are needed.
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  • The study analyzed the success and complications of using excimer laser coronary atherectomy (ELCA) in patients experiencing balloon failure during percutaneous coronary intervention (PCI), with a focus on chronic total occlusions (CTO).
  • Out of 58 identified balloon failure cases treated with ELCA, the overall procedure success rate was 91%, with ELCA used alone or in combination with rotational atherectomy (RA) showing favorable outcomes.
  • The findings suggest that ELCA is a safe and effective option for treating difficult lesions in PCI, although there were some complications, including a serious incident leading to mortality.
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