Publications by authors named "Nima Hasaniani"

Multiple sclerosis (MS) is a neurological autoimmune disorder predominantly afflicting young adults. The etiology of MS is intricate, involving a variety of environmental and genetic factors. Current research increasingly focuses on the substantial contribution of gut microbiota in MS pathogenesis.

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Exosomes are bilayer lipid vesicles that are released by cells and contain proteins, nucleic acids, and lipids. They can be internalized by other cells, inducing inflammatory responses and instigating toxicities in the recipient cells. Exosomes can also serve as therapeutic vehicles by transporting protective cargo to maintain homeostasis.

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Metal-organic frameworks (MOFs) are known as potential pharmaceutical carriers because of their structure. Here, we evaluated the sub-acute administrations of MOF-5 on behavioral parameters, oxidative stress, and inflammation levels in rats. Thirty-two male Wistar rats received four injections of saline or MOF-5 at different doses which were 1, 10, and 50 mg/kg via caudal vein.

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Article Synopsis
  • There is strong evidence of a two-way interaction between gut microbiota and the central nervous system, impacting neurodegenerative disorders and regenerative processes.
  • The study examined the effects of probiotics, specifically Lactobacillus casei and Bifidobacterium breve, on various performance and health markers in a rat model of induced demyelination.
  • Results indicated that probiotic supplementation improved cognitive performance and antioxidant levels, with B. breve showing greater efficacy in reducing demyelination and oxidative stress, suggesting it could aid in treating multiple sclerosis.
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