Subcutaneous immunotherapy with depigmented-polymerized allergen extracts: a systematic review and meta-analysis.

Background: Double-blind, placebo-controlled trials (DBPCTs) have confirmed the efficacy of allergen-specific immunotherapy (AIT) with depigmented-polymerized allergen extracts (DPAEs). This systematic review evaluates the efficacy of AIT using different allergens in different severity stages of rhinoconjunctivitis with or without asthma in the pollen studies and asthma and rhinitis in the house dust mite studies in comparison to placebo.

Methods: We used MEDLINE, Embase, CENTRAL and LILACS databases to review DBPCTs published until July 2016.