Systematic review of the molecular basis of hereditary breast and ovarian cancer syndrome in Brazil: the current scenario.

Background: A detailed understanding of the genetic basis of cancer is of great interest to public health monitoring programs. Although many studies have been conducted in Brazil, a global view on the molecular profile related to hereditary breast and ovarian cancer (HBOC) in this large and heterogeneous population is lacking.

Methods: A systematic review following the PRISMA guidelines was conducted in three electronic databases (PubMed, BIREME and SciELO).