Publications by authors named "Nils Sjoholm"
Purpose: [(18)F]FEDAA1106 is a recently developed positron emission tomography (PET) radioligand for in vivo quantification of the 18 kDa translocator protein [TSPO or, as earlier called, the peripheral benzodiazepine receptor (PBR)]. TSPO imaging is expected to be useful for the clinical evaluation of neuroinflammatory diseases. The aim of this study was to provide dosimetry estimates for [(18)F]FEDAA1106 based on human whole-body PET measurements.
View Article and Find Full Text PDFAdvancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT.
Eur J Nucl Med Mol Imaging
October 2009
Purpose: Image reconstruction including the modelling of the point spread function (PSF) is an approach improving the resolution of the PET images. This study assessed the quantitative improvements provided by the implementation of the PSF modelling in the reconstruction of the PET data using the High Resolution Research Tomograph (HRRT).
Methods: Measurements were performed on the NEMA-IEC/2001 (Image Quality) phantom for image quality and on an anthropomorphic brain phantom (STEPBRAIN).
Purpose: (S,S)-[(18)F]FMeNER-D(2) is a recently developed positron-emission tomography (PET) radioligand for in vivo quantification of the norepinephrine transporter system. The aim of this study was to provide dosimetry estimates for (S,S)-[(18)F]FMeNER-D(2) based on human whole-body PET measurements.
Methods: PET scans were performed for a total of 6.
Background: (S,S)-[F]FMeNER-D2 is a recently developed norepinephrine transporter ligand which is a potentially useful radiotracer for mapping the brain and heart norepinephrine transporter in vivo using positron emission tomography. In this work, we quantified the biodistribution over time and radiation exposure to multiple organs with (S,S)-[F]FMeNER-D2.
Methods: Whole-body images were acquired for 21 time points in two cynomolgus monkeys for approximately 270 min after injection of radioligand.