Publications by authors named "Nils P Sommer"

This study evaluated nematodes as an alternative to live when provided in a co-feeding regime to Pacific white shrimp () post-larvae (PL) reared in a biofloc nursery system. A 20-day experiment employing PL was performed for an evaluation of four dietary groups: control [C] (fed exclusively with a dry commercial feed); artificial [AA] (dry feed composed of extracted and processed cysts and dry commercial feed); live and dry commercial feed [LA]; and nematodes and dry commercial feed [N] ( sp. dry nematodes).

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Purpose: Modern, personalized treatment concepts in oncology require an interdisciplinary and multiprofessional collaboration. In addition to its relevance in patient care, interdisciplinary collaboration is also becoming increasingly important in clinical research as well as medical education and resident training in oncology.

Methods: Between November 2021 and March 2022, an online survey was conducted among German early career research groups, represented by Young Oncologists United (YOU).

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Abdominal surgery results in an activation of immune cells of the bowel wall and a consecutive cytokine and nitric oxide (NO) release leading to an inflammation of the muscularis externa and a bowel paralysis, the so-called postoperative ileus (POI). In addition to the local inflammation, major surgical trauma can also lead to a variable pronounced systemic inflammation up to its maximum variant, the systemic inflammatory response syndrome (SIRS), with hypotension, capillary leak and a breakdown of the intestinal barrier function followed by multi-organ dysfunction (MODS). Until now, neither for SIRS nor for POI, a prophylaxis or an evidence-based treatment exists.

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Article Synopsis
  • Postoperative Ileus (POI) is a common complication after abdominal surgery, affecting 10-27% of patients, leading to discomfort, longer hospital stays, and increased healthcare costs.
  • The review discusses POI's causes and highlights effective preventive measures, such as multimodal pain management and minimally invasive surgical techniques, though no evidence-based treatment exists once POI develops.
  • Current research lacks a clear definition of POI and consistent endpoints, which hinders progress and could improve treatment if addressed.
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