LayNii: A software suite for layer-fMRI.

High-resolution fMRI in the sub-millimeter regime allows researchers to resolve brain activity across cortical layers and columns non-invasively. While these high-resolution data make it possible to address novel questions of directional information flow within and across brain circuits, the corresponding data analyses are challenged by MRI artifacts, including image blurring, image distortions, low SNR, and restricted coverage. These challenges often result in insufficient spatial accuracy of conventional analysis pipelines.

Clinical Validation of a 3-Dimensional Ultrafast Cardiac Magnetic Resonance Protocol Including Single Breath-Hold 3-Dimensional Sequences.

Objectives: This study sought to clinically validate a novel 3-dimensional (3D) ultrafast cardiac magnetic resonance (CMR) protocol including cine (anatomy and function) and late gadolinium enhancement (LGE), each in a single breath-hold.

Background: CMR is the reference tool for cardiac imaging but is time-consuming.

Methods: A protocol comprising isotropic 3D cine (Enhanced sensitivity encoding [SENSE] by Static Outer volume Subtraction [ESSOS]) and isotropic 3D LGE sequences was compared with a standard cine+LGE protocol in a prospective study of 107 patients (age 58 ± 11 years; 24% female).

Steering of Magnetic Devices With a Magnetic Particle Imaging System.

Small magnetic devices have been steered in arbitrary direction and with variable force using a preclinical demonstrator system for magnetic particle imaging (MPI). Fast localization due to the high imaging rate of over 40 volumes/s and strong forces due to the high field gradient of more than 1 T/m render an MPI system, a good platform for image-guided steering of magnetic devices. In this paper, these capabilities are demonstrated in phantom experiments, where a closed feedback loop has been realized to exert translational forces in horizontal and vertical direction on a magnetic device moving in a viscous medium.

Optimization of dual-saturation single bolus acquisition for quantitative cardiac perfusion and myocardial blood flow maps.

Background: In-vivo quantification of cardiac perfusion is of great research and clinical value. The dual-bolus strategy is universally used in clinical protocols but has known limitations. The dual-saturation acquisition strategy has been proposed as a more accurate alternative, but has not been validated across the wide range of perfusion rates encountered clinically.