Injury risk curves to guide safe speed limits on Swedish roads using German crash data supplemented with estimated non-injury crashes.

Vision Zero postulates that no one should be killed or seriously injured in road traffic; therefore, it is necessary to define evidence-based speed limits to mitigate impact severity. The overall aims to guide the definition of safe speeds limits by establishing relations between impact speed and the risk of at-least-moderate (MAIS2+) and at-least-severe (MAIS3+) injuries for car occupants in frontal and side crashes in Sweden. As Swedish in-depth data are unavailable, the first objective was to assess the applicability of German In-depth Accident Study (GIDAS) data to Sweden.

Rib and sternum fracture risks for restrained occupants in frontal car crashes.

Objective: Most car occupant fatalities occur in frontal crashes and the thorax is the most frequently injured body region. The objectives of the study were, firstly, to quantify the relation between risk factors (such as speed and occupant age) and rib and sternum fracture injury probability in frontal car crashes, and, secondly, to evaluate whether rib fracture occurrence can predict sternum fractures.

Methods: Weighted German data from 1999-2021 were used to create the injury risk curves to predict both, at least moderate and at least serious, rib and sternum fracture risks.

Assessing injury risks of reclined occupants in a frontal crash preceded by braking with varied seatbelt designs using the SAFER Human Body Model.

Objective: This study investigated the effects of different seatbelt geometries and load-limiting levels on the kinematics and injury risks of a reclined occupant during a whole-sequence frontal crash scenario, using simulations with the Active SAFER Human Body Model (Active SHBM).

Methods: The Active SHBM was positioned in a reclined position (50°) on a semi-rigid seat model. A whole-sequence frontal crash scenario, an 11 m/s Automated Emergency Braking (AEB) phase followed by a frontal crash at 50 km/h, was simulated.

Repositioning forward-leaning passengers by seatbelt pre-pretensioning.

Objective: The study determined the seatbelt pre-pretensioner force needed and the time required to reposition average male front-seat passengers from forward-leaning to upright using finite element simulations of the Active SAFER Human Body Model (Active SHBM).

Methods: The Active SHBM was positioned in an initial forward-leaning position (29° forward from upright) on a deformable vehicle seat. A pre-pretensioner was modeled as a pre-loaded spring and its ability to reposition the forward-leaning Active SHBM to an upright position was simulated for twenty-four different pre-crash conditions.

Evaluation of full-face, open-face, and airbag-equipped helmets for facial impact protection.

Objective: Two-wheeler riders frequently sustain injuries to the head and face in real-world crashes, including traumatic brain injury, basilar skull fracture, and facial fracture. Different types of helmets exist today, which are recognized as preventing head injuries in general; however, their efficacy and limitations in facial impact protection are underexplored. Biofidelic surrogate test devices and assessment criteria are lacking in current helmet standards.

Assessing the applicability of impact speed injury risk curves based on US data to defining safe speeds in the US and Sweden.

Vision Zero is an approach to road safety that aims to eliminate all traffic-induced fatalities and lifelong injuries. To reach this goal, a multi-faceted safe system approach must be implemented to anticipate and minimize the risk associated with human mistakes. One aspect of a safe system is choosing speed limits that keep occupants within human biomechanical limits in a crash scenario.

Can non-crash naturalistic driving data be an alternative to crash data for use in virtual assessment of the safety performance of automated emergency braking systems?

Introduction: Developers of in-vehicle safety systems need to have data allowing them to identify traffic safety issues and to estimate the benefit of the systems in the region where it is to be used, before they are deployed on-road. Developers typically want in-depth crash data. However, such data are often not available.

Crash characteristics and injury risk of adult car occupants in near-side impacts.

Objective: In the US, 27% of car occupant fatalities occur in side-impacts. Near-side impacts cause more serious injuries than far-side impacts. Car occupant safety overall has improved, but rear-seat occupant protection lags behind front-seat protection.

Motorcyclist injuries: Analysis of German in-depth crash data to identify priorities for injury assessment and prevention.

Globally there are more than 350,000 PTW fatalities each year. Safety concepts to protect Powered Two-Wheeler (PTW) riders exist and are being developed further, but they need appropriate procedures and test tools (Anthropometric Test Devices (ATDs) for physical testing and Human Body Models (HBMs) for virtual testing) to direct and promote those developments. To aid further development of the tools, we aim to rank the frequency of specific injuries arising from the prevalent impact types, discuss how current ATDs and HBMs are equipped to assess these injuries, and suggest what further development should be prioritized.

Evaluating automated emergency braking performance in simulated car-to-two-wheeler crashes in China: A comparison between C-NCAP tests and in-depth crash data.

Automated Emergency Braking (AEB) is an effective way to prevent crashes from happening or mitigate their severity. Because riders of two-wheelers (TWs) are among the most vulnerable road users, New Car Assessment Programs, like the China New Car Assessment Program (C-NCAP), have recently introduced test scenarios for the assessment of AEB for cars encountering TWs (TW-AEB). The main aim of this study was to determine how well two different C-NCAP test scenario datasets reflect real-world crash scenarios for the purpose of assessing TW-AEB performance.

Rib Cortical Bone Fracture Risk as a Function of Age and Rib Strain: Updated Injury Prediction Using Finite Element Human Body Models.

To evaluate vehicle occupant injury risk, finite element human body models (HBMs) can be used in vehicle crash simulations. HBMs can predict tissue loading levels, and the risk for fracture can be estimated based on a tissue-based risk curve. A probabilistic framework utilizing an age-adjusted rib strain-based risk function was proposed in 2012.

Electrolyte disorders secondary to venetoclax.

Emerging cancer drugs introduce new forms of nephrotoxicity that may also present as electrolyte disorders. Here, we report a patient with non-Hodgkin lymphoma who developed severe hypokalaemia with concurrent hypophosphataemia, hypocalcaemia and hypomagnesaemia secondary to venetoclax. Although electrolyte disorders have been reported during treatment with venetoclax, these were ascribed to tumour lysis prophylaxis.

Defining crash configurations for Powered Two-Wheelers: Comparing ISO 13232 to recent in-depth crash data from Germany, India and China.

The motorcyclist safety standard ISO 13232, based on crash data from Europe and the USA from the 1970s, still sets the direction for the development and evaluation of protective measures today. However, it is unclear how relevant the crash configurations in the standard are to present-day motorcycle crashes in Europe, the USA and other parts of the world. We analyzed recent in-depth crash data from Germany, India and China, examining powered two-wheeler (PTW) crash configurations in which at least one police-reported serious injury was present.

Modelling discomfort: How do drivers feel when cyclists cross their path?

Many cyclist fatalities occur on roads when crossing a vehicle path. Active safety systems address these interactions. However, the driver behaviour models that these systems use may not be optimal in terms of driver acceptance.

Simulating Automated Emergency Braking with and without Torricelli Vacuum Emergency Braking for cyclists: Effect of brake deceleration and sensor field-of-view on accidents, injuries and fatalities.

This study estimates how many additional cyclist accidents, injuries or fatalities are avoided or mitigated by adding a system which increases braking levels, the Torricelli Vacuum Emergency Brake (VEB), to a state-of-the-art Automated Emergency Braking (AEB) system. To obtain a realistic state-of-the-art AEB system, the AEB parameter settings were defined to fulfil but not exceed the performance necessary to achieve a full score in the European New Car Assessment Program (Euro NCAP). The systems are simulated in a simple but realistic simulation model in MATLAB with varying brake deceleration and sensor field-of-view (FoV).

How do drivers negotiate intersections with pedestrians? The importance of pedestrian time-to-arrival and visibility.

Forward collision warning (FCW) and autonomous emergency braking (AEB) systems are increasingly available and prevent or mitigate collisions by alerting the driver or autonomously braking the vehicle. Threat-assessment and decision-making algorithms for FCW and AEB aim to find the best compromise for safety by intervening at the "right" time: neither too early, potentially upsetting the driver, nor too late, possibly missing opportunities to avoid the collision. Today, the extent to which activation times for FCW and AEB should depend on factors such as pedestrian speed and lane width is unknown.

A clustering approach to developing car-to-two-wheeler test scenarios for the assessment of Automated Emergency Braking in China using in-depth Chinese crash data.

Two-wheeled vehicles (motorized and non-motorized, referred to as TWs) are an important part of the transport system in China. They also represent an important challenge for road safety, with many TW user fatalities and injuries every year. Recently, active safety systems for cars, such as Automated Emergency Braking (AEB), promise to reduce road traffic fatalities and injuries.

Intersection AEB implementation strategies for left turn across path crashes.

Left turn across path with traffic from the opposite direction (LTAP/OD) is the second most frequent car-to-car intersection crash type after straight crossing path (SCP) in Germany and the United States. Intersection automated emergency braking (AEB) for passenger cars can address these crashes. This study investigates 2 implementation strategies of intersection AEB addressing LTAP/OD crashes: (1) only the turning car is equipped with an intersection AEB and (2) turning and straight-heading cars are equipped with an intersection AEB.

Motorcyclist injury risk as a function of real-life crash speed and other contributing factors.

The Vision Zero approach advocates for a road transport system designed with human injury tolerance and human fallibility as its basis. While biomechanical limits and the relationship between speed and injury outcome has been extensively investigated for car occupants and pedestrians, research analyzing this relationship for motorcyclists remains limited. The aim of this study was to address this issue by developing multivariate injury risk models for motorcyclists that estimate the relationship between speed and injury severity.

Mycophenolate Mofetil Attenuates DOCA-Salt Hypertension: Effects on Vascular Tone.

Inflammation is increasingly recognized as a driver of hypertension. Both genetic and pharmacological inhibition of B and T cells attenuates most forms of experimental hypertension. Accordingly, the immunosuppressive drug mycophenolate mofetil (MMF) reduces blood pressure in the deoxycorticosterone acetate (DOCA-) salt model.

Increased Urinary Extracellular Vesicle Sodium Transporters in Cushing Syndrome With Hypertension.

Context: Increased renal sodium reabsorption contributes to hypertension in Cushing syndrome (CS). Renal sodium transporters can be analyzed noninvasively in urinary extracellular vesicles (uEVs).

Objective: To analyze renal sodium transporters in uEVs of patients with CS and hypertension.

Market penetration of intersection AEB: Characterizing avoided and residual straight crossing path accidents.

Car occupants account for one third of all junction fatalities in the European Union. Driver warning can reduce intersection accidents by up to 50 percent; adding Autonomous Emergency Braking (AEB) delivers a reduction of up to 70 percent. However, these findings are based on an assumed 100 percent equipment rate, which may take decades to achieve.

The potential of clustering methods to define intersection test scenarios: Assessing real-life performance of AEB.

Intersection accidents are frequent and harmful. The accident types 'straight crossing path' (SCP), 'left turn across path - oncoming direction' (LTAP/OD), and 'left-turn across path - lateral direction' (LTAP/LD) represent around 95% of all intersection accidents and one-third of all police-reported car-to-car accidents in Germany. The European New Car Assessment Program (Euro NCAP) have announced that intersection scenarios will be included in their rating from 2020; however, how these scenarios are to be tested has not been defined.

Real life safety benefits of increasing brake deceleration in car-to-pedestrian accidents: Simulation of Vacuum Emergency Braking.

The objective of this study is to predict the real-life benefits, namely the number of injuries avoided rather than the reduction in impact speed, offered by a Vacuum Emergency Brake (VEB) added to a pedestrian automated emergency braking (AEB) system. We achieve this through the virtual simulation of simplified mathematical models of a system which incorporates expected future advances in technology, such as a wide sensor field of view, and reductions in the time needed for detection, classification, and brake pressure build up. The German In-Depth Accident Study database and the related Pre Crash Matrix, both released in the beginning of 2016, were used for this study and resulted in a final sample of 526 collisions between passenger car fronts and pedestrians.

Modelling how drivers respond to a bicyclist crossing their path at an intersection: How do test track and driving simulator compare?

Bicyclist fatalities are a great concern in the European Union. Most of them are due to crashes between motorized vehicles and bicyclists at unsignalised intersections. Different countermeasures are currently being developed and implemented in order to save lives.