Socioeconomic determinants potentially underlying differential global SARS-CoV-2 testing capacity: an ecological study.

Objectives: To analyse the relationships between SARS-CoV-2 laboratory testing capacity (TC) and socioeconomic factors (wealth, governance and social inequality) across 109 countries in 2020-2021, to identify potential determinants of global disparities in TC during the COVID-19 pandemic.

Design: An ecological study using regression analyses to explore the associations between TC and socioeconomic determinants within and across global regions.

Setting/participants: Data from 109 countries from Our World in Data, the WHO, the United Nations and others grouped into six geographic and sociodemographic regions (global burden of disease regions), were analysed separately for the years 2020-2021 based on differential vaccine availability and country-level responses throughout the pandemic.

Secondary sclerosing cholangitis in patients suffering cardiogenic shock.

Aims: Cardiogenic shock (CS) patients suffer from severe organ hypoperfusion, yet the incidence of secondary sclerosing cholangitis in critically ill patients (SSC-CIP) in CS is poorly described. Given the limited evidence and severity of this syndrome, we aimed to further investigate SSC-CIP in the context of CS.

Methods And Results: 24 251 total CS patients admitted between 1 January 2010 and 31 December 2023 were retrospectively screened for the diagnosis of SSC-CIP across nine German tertiary care centers.

Characterization of Baseline Lung Allograft Dysfunction in Single Lung Transplant Recipients.

Background: Baseline lung allograft dysfunction (BLAD) is characterized by the failure to achieve normal baseline lung function after double lung transplantation (DLTX) and is associated with a high risk of mortality. In single lung transplant (SLTX) recipients, however, cutoff values and associated factors have not been explored. Here, we aimed to define BLAD in SLTX recipients, investigate its impact on allograft survival, and identify potential risk factors for BLAD in SLTX recipients.

Heparin-Induced Thrombocytopenia in Patients Suffering Cardiogenic Shock.

Objectives: Cardiogenic shock (CS) is associated with high mortality. Patients treated for CS mostly require heparin therapy, which may be associated with complications such as heparin-induced thrombocytopenia (HIT). HIT represents a serious condition associated with platelet decline and increased hypercoagulability and remains a poorly researched field in intensive care medicine.

The role of coronary artery disease in lung transplantation: a propensity-matched analysis.

Background And Aims: Candidate selection for lung transplantation (LuTx) is pivotal to ensure individual patient benefit as well as optimal donor organ allocation. The impact of coronary artery disease (CAD) on post-transplant outcomes remains controversial. We provide comprehensive data on the relevance of CAD for short- and long-term outcomes following LuTx and identify risk factors for mortality.

A contemporary training concept in critical care cardiology.

Critical care cardiology (CCC) in the modern era is shaped by a multitude of innovative treatment options and an increasingly complex, ageing patient population. Generating high-quality evidence for novel interventions and devices in an intensive care setting is exceptionally challenging. As a result, formulating the best possible therapeutic approach continues to rely predominantly on expert opinion and local standard operating procedures.

Benefit of monoclonal antibodies in early treatment of COVID-19 after lung transplantation: a retrospective analysis in two centres.

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