Publications by authors named "Nils C Krapoth"
The extracellular parasite Trypanosoma brucei evades the immune system of the mammalian host by periodically exchanging its variant surface glycoprotein (VSG) coat. Hereby, only one VSG gene is transcribed from one of 15 subtelomeric so-called bloodstream form expression sites (BES) at any given timepoint, while all other BESs are silenced. VSG gene expression is altered by homologous recombination using a large VSG gene repertoire or by a so-called in situ switch, which activates a previously silent BES.
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- Ubiquitin is a key posttranslational modifier that influences various cellular processes through its ability to form different types of polymeric chains.
- Researchers have developed a new system called "Ubiquiton" that includes engineered ubiquitin ligases and specific tags for precise, inducible polyubiquitylation in yeast and mammalian cells.
- This tool has been validated for various protein types and can modulate their localization and stability, making it a valuable resource for studying the role of polyubiquitin chains in different biological contexts.