Publications by authors named "Niloofar Seighali"
Myo-inositol may be efficient to improve sperm parameters to increase the chance of fertility. Although, the data are controversial. This study aimed to assess the impact of Myo-inositol supplements on semen quality and in vitro fertilization (IVF) outcomes.
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- Pediatric migraines negatively affect kids' daily lives and school performance, making it essential to find effective treatments for prevention.
- A network meta-analysis was conducted to compare the efficacy and safety of different oral medications for stopping migraine episodes in children.
- The study aimed to analyze data from various clinical trials to determine how well these treatments work and identify any potential side effects.
Background: We sought to conduct this comprehensive systematic review and meta-analysis to assess the prevalence of depression, anxiety, and sleep disturbance in Iranian medical students and resident physicians.
Methods: A systematic search was conducted on 23 December 2023 in PubMed/MEDLINE, Web of Science, Scopus, and Iranian national databases. We pooled the prevalence of individual studies using the random effect model.
Article Synopsis
- CAR T-cell therapy is an innovative treatment for certain blood cancers, but it's linked to serious cardiovascular events (CVE), including arrhythmias and heart failure.
- A systematic review analyzed 23 studies, revealing that over half of patients experienced CVEs, particularly those with severe cytokine release syndrome (CRS).
- The findings emphasize the need for close monitoring and personalized care to address potential cardiotoxic effects, while also noting that cardiac mortality rates appear to be low, indicating room for improvement in prevention strategies.
Dexmedetomidine administration as a possible cognitive enhancer through increasing the level of brain-derived neurotrophic factors in surgical patients: a systematic review and meta-analysis.
BMC Anesthesiol
July 2024
Objective: This meta-analysis aimed to investigate the effect of dexmedetomidine on brain-derived neurotrophic factor (BDNF) levels in individuals undergoing various medical procedures. We systematically searched electronic databases and manually identified relevant articles to assess the impact of dexmedetomidine on BDNF levels in surgical patients.
Methods: A comprehensive literature search was conducted in PubMed, Scopus, Embase, and Web of Science databases with no language restrictions.
Background: Obesity is a global health concern, and understanding its prevalence among medical students is crucial for shaping targeted interventions. This systematic review and meta-analysis aim to comprehensively assess the prevalence of obesity and overweight among medical students.
Methods: A systematic literature search was conducted across major databases, including PubMed, Scopus, and Web of Science, in order to identify relevant studies that evaluated obesity and overweight among medical students.
Context: Saffron, a natural remedy with potential antidepressant and anxiolytic properties, has gained attention as a potential therapeutic option.
Objective: This systematic review and meta-analysis aimed to evaluate the comparative effectiveness of saffron versus selective serotonin reuptake inhibitors (SSRIs) in treating depression and anxiety.
Data Source: Electronic databases, including PubMed, Embase, Scopus, Web of Science, and the Cochrane database, were searched from inception to April 31, 2023.
Background: Beyond its ability to decrease cholesterol, statin medication has been proved to have a variety of pleiotropic effects, such as anti-inflammatory and immunomodulatory effects. Statins are an appealing therapeutic option for individuals with infective endocarditis because of these effects, as the condition is linked to a strong inflammatory response.
Methods: A comprehensive search was done in Medline/PubMed, Cochrane database (CENTRAL), and Google Scholar to identify relevant studies reporting outcomes of interest (rate of mortality, intensive care unit admission, and embolic events) comparing those who are on statin therapy to nonusers were included.
Background: Post COVID-19 syndrome, also known as "Long COVID," is a complex and multifaceted condition that affects individuals who have recovered from SARS-CoV-2 infection. This systematic review and meta-analysis aim to comprehensively assess the global prevalence of depression, anxiety, and sleep disorder in individuals coping with Post COVID-19 syndrome.
Methods: A rigorous search of electronic databases was conducted to identify original studies until 24 January 2023.
Background: The identification of new prognostic tools for the prediction of burn patients' morbidity outcomes is necessary. Considering the feasibility of frailty assessment in the clinical setting, we aim to systematically review the literature on the associations between frailty and adverse outcomes in burn patients.
Methods: Studies were retrieved from MEDLINE (through PubMed), Web of Science, Scopus, and Embase from their inception up to 8 September 2022.
Brain-Derived Neurotrophic Factor (BDNF) is a vital protein involved in neuronal development, survival, and plasticity. Alcohol consumption has been implicated in various neurocognitive deficits and neurodegenerative disorders. However, the impact of alcohol on BDNF blood levels remains unclear.
View Article and Find Full Text PDFIntroduction: Extracorporeal cardiopulmonary resuscitation (ECPR) is a resuscitation method for patients with refractory out-of-hospital cardiac arrest (OHCA). However, evidence from randomized controlled trials (RCTs) is lacking.
Methods: We searched several electronic databases until March 2023 for RCTs comparing ECPR with conventional CPR in OHCA patients.
Many individuals have been suffering from consistent neurological and neuropsychiatric manifestations even after the remission of coronavirus disease (COVID-19). Brain-derived neurotrophic factor (BDNF) is a protein involved in the regulation of several processes, including neuroplasticity, neurogenesis, and neuronal differentiation, and has been linked to a range of neurological and psychiatric disorders. In this study, we aimed to synthesize the available evidence on the profile of BDNF in COVID-19.
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- Researchers examined the effectiveness of lower versus higher oxygen targets in patients who experienced out-of-hospital cardiac arrest (OHCA), focusing on patient outcomes like mortality and neurological recovery.
- They analyzed data from nine randomized controlled trials involving nearly 2,000 patients, finding no significant differences in all-cause mortality, neurological outcomes, neuron-specific enolase levels, or ICU length of stay between conservative and liberal oxygen therapy groups.
- The study concluded that conservative oxygen therapy did not lead to better outcomes than liberal therapy, and it suggests that more extensive research is necessary to establish clearer guidelines on oxygen use post-resuscitation.
Anthracycline chemotherapy causes cardiotoxicity, and the evidence regarding the benefit of concomitant statin use in reducing it remains uncertain. We conducted a meta-analysis of studies using statins and anthracyclines by searching PubMed, Embase, the Cochrane Library, and ClinicalTrials.gov from inception until April 10, 2023.
View Article and Find Full Text PDFBackground: ATLL (Adult T-Cell Leukemia/Lymphoma) is an aggressive hematological malignancy. This T-cell non-Hodgkin lymphoma, caused by the human T-cell leukemia virus type 1 (HTLV-1), is challenging to treat. There is no known treatment for ATLL as of yet.
View Article and Find Full Text PDFBackground: Numerous vaccination research experiments have been conducted on non-primate hosts to prevent or control HTLV-1 infection. Therefore, reviewing recent advancements for status assessment and strategic planning of future preventative actions to reduce HTLV-1 infection and its consequences would be essential.
Methods: MEDLINE, Scopus, Web of Science, and Clinicaltrials.
Objective: To synthesize the published citations to determine the association between glucose metabolism tests and recurrent pregnancy loss (RPL).
Method: The electronic databases including PubMed, Scopus and Web of Science were searched for the original articles that evaluated the correlation between glucose metabolism tests including fasting blood glucose (FBG), fasting insulin (FI), homeostatic model assessment for insulin resistance (HOMA-IR), the rate of individuals with HOMA-IR > 4.5, insulin resistance, fasting glucose/fasting insulin (FG/FI) and FG/FI > 4.
Background And Aims: This systematic review and meta-analysis aimed to evaluate the current evidence available to investigate clinical outcomes between patients with type 1 and type 2 diabetes.
Methods: MEDLINE (Pubmed), Scopus, Web of Science, Cochrane library, Google scholar and Clinicaltrials.gov were searched.