An Insight Into the Anxiolytic Effects of Lignans (Phyllanthin and Hypophyllanthin) and Tannin (Corilagin) Rich Extracts of : An and approaches.

Unlabelled: The extracts and the compounds isolated from Phyllanthus amarus Schumm and Thonn (Family: Euphorbiaceae) have shown a wide spectrum of pharmacological activities including antiviral, antibacterial, antiplasmodial, antimalarial, antimicrobial, anticancer, antidiabetic, hypolipidemic, antioxidant, hepatoprotective, nephroprotective and diurectic properties.

Background: This investigation was aimed at exploring the anxiolytic potential of Phyllanthus amarus standardized extracts and predict probable role of marker phyto constitutents.

Objective And Methods: Three standardized extracts of Phyllanthus amarus plant viz.

Pharmacological characterization of carrageenan induced heat muscle hyperalgesia in rats using non-selective, preferential and selective COX-2 inhibitors.

Background: Previous studies have shown that unilateral injection of carrageenan into the gastrocnemius muscle produces chronic thermal and mechanical hyperalgesia.

Aim: In the present study, we have characterized this model of muscoskeletal inflammatory pain, by evaluating the antihyperalgesic effects of selective and non-selective COX-2 inhibitors after systemic administration.

Materials And Methods: Rats were injected with 3% carrageenan in the left gastrocnemius muscle and hyperalgesia to heat stimuli (measured as decreased withdrawal latency) to paws was assessed before and at varying times after injection, till end of 2nd week.

Cardioprotective effect of methanolic extract of Ixora coccinea Linn. leaves on doxorubicin-induced cardiac toxicity in rats.

Objectives: To investigate the effect of methanolic extract of Ixora coccinea Linn. (MEIC) leaves against doxorubicin-induced cardiac toxicity in rats.

Material And Methods: Albino Wistar rats were pretreated with the methanolic extract of Ixora coccinea Linn.