β-carbolines RCC and C5 induce the death of intracellular amastigotes.

Cutaneous leishmaniasis is caused by spp., and its treatment is limited. The β-carbolines have shown activity against kinetoplastids.

Oral treatment with T6-loaded yeast cell wall particles reduces the parasitemia in murine visceral leishmaniasis model.

Yeast cell wall particles isolated from Saccharomyces cerevisiae (scYCWPs) have a rich constitution of β-glucan derived from the cell wall. After removing intracellular contents, β-glucan molecules are readily recognized by dectin-1 receptors, present on the cytoplasmic membrane surface of the mononuclear phagocytic cells and internalized. Leishmania spp.