Immun Inflamm Dis
October 2022
Background: Psoriasis is a common, chronic, inflammatory skin disease that involves changes taking place as a result of activation of the immune system. Suppressor of cytokine signaling proteins (SOCS) are intracellular proteins that act as endogenous inhibitors of proinflammatory pathways triggered by various cytokines. In this study, the relationship between psoriasis disease and SOCS gene polymorphisms is investigated in relation to the pathogenesis of psoriasis to clarify the psoriasis susceptibility profile.
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March 2016
Interferon-alpha is one of the major immune modulating agents used in current oncology practice, including melanoma. We present a case of psoriasis exacerbation induced by INF-α in a patient with melanoma.
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