Publications by authors named "Nilguen Solak"

Mpox, formerly known as monkeypox, is a zoonotic disease caused by the Mpox virus (MPXV), which has recently attracted global attention due to its potential for widespread outbreaks. Initially identified in 1958, MPXV primarily spreads to humans through contact with infected wild animals, particularly rodents. Historically confined to Africa, the virus has expanded beyond endemic regions, with notable outbreaks in Europe and North America in 2022, especially among men who have sex with men (MSM).

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This paper describes a new species of Halamphora - and records for the first time for the coasts of Indonesia. The study utilized light and scanning electron microscopy to meticulously examine the morphology. These species were found at Kuta Beach on the island of Lombok in Indonesia in highly saline sandy environments.

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Purpose: Health literacy is a complex issue that affects the health outcomes of surgical patients. This study aimed to determine the health literacy of general surgery patients.

Design: A descriptive cross-sectional study.

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Background/aim: There is currently no data from Türkiye on whether, following a diagnosis of asthma, patients are given an asthma action plan to implement. There is also no data on whether patients can manage their treatment based on the provided asthma action plans. The present study aimed to determine the use of asthma action plans in Türkiye and the awareness levels of patients about these plans.

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Objectives: The shape is commonly used to describe the objects. State-of-the-art algorithms in medical imaging are predominantly diverging from computer vision, where voxel grids, meshes, point clouds, and implicit surface models are used. This is seen from the growing popularity of ShapeNet (51,300 models) and Princeton ModelNet (127,915 models).

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Rationale And Objectives: Magnetic resonance imaging (MRI) is a vital tool for diagnosing neurological disorders, frequently utilising gadolinium-based contrast agents (GBCAs) to enhance resolution and specificity. However, GBCAs present certain risks, including side effects, increased costs, and repeated exposure. This study proposes an innovative approach using generative adversarial networks (GANs) for virtual contrast enhancement in brain MRI, with the aim of reducing or eliminating GBCAs, minimising associated risks, and enhancing imaging efficiency while preserving diagnostic quality.

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  • The study explores how iron oxide-based magnetic nanoparticles (MNPs) interact with cells through protein secretion and employs machine learning-assisted SERS for analysis.
  • The researchers developed various MNPs with different surface modifications, significantly impacting their size, shape, and charge, which were assessed using techniques like transmission electron microscopy (TEM).
  • Results showed that smaller MNPs adhered better to cells, and those encapsulated with polyethylenimine (PEI) enhanced the secretion of the recombinant azurin protein, highlighting the important role of MNP properties in cell interactions and potential applications in protein delivery.
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  • Bipolar disorder (BD) is a mental health condition marked by severe mood swings, affecting about 1% of the population, with genetics and environment playing a role in its development.
  • * This study focused on analyzing gene variants in three families with BD using whole-exome sequencing, examining six patients in total.
  • * Researchers identified seven genes potentially linked to BD, including two novel variants, and emphasized the need for larger studies to explore these findings' implications for diagnosis and treatment.
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Objective: The aim of this study was to evaluate the correlation between changes in the inferior vena cava collapsibility index and subclavian vein collapsibility index in patients undergoing passive leg raising tests in the intensive care unit, considering that respiratory changes affecting the inferior vena cava may similarly affect the subclavian vein.

Methods: This single-center observational study was conducted on patients aged between 18 and 85 years who underwent passive leg raising in the intensive care unit. When the patient was 45° above the bed, the inferior vena cava and subclavian vein were displayed using ultrasonography; subclavian vein collapsibility index and inferior vena cava collapsibility index values were calculated.

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  • - The study identifies a new diatom species from the highly alkaline Lake Van in Turkey, characterized through light and scanning electron microscopy on both wild and cultivated samples.
  • - Genome analysis revealed that the two monoclonal cultures have very similar DNA sequences with only a few mutations, particularly in the mitochondrial and plastid genomes, indicating some differences in protein coding genes.
  • - Phylogenetic analysis placed the new diatom species within the K clade, known for its diversity of species from hypersaline to freshwater environments.
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Depression is responsible for neuropathies such as decreased neurogenesis and increased dendritic atrophy. There is information that antidepressant treatments have an effect by increasing hippocampal neurogenesis and neurotrophic factor expression. The neuropeptide Y1 (NPY1R) receptor agonist has been suggested to have anxiolytic effects.

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  • - The study examined how altitude affects the gut microbiome of Anatolian Blind Mole Rats using 16S rRNA metabarcoding, noting significant changes in bacterial composition based on elevation, particularly with facultatively anaerobic bacteria being more abundant at higher altitudes.
  • - Microbiome alpha diversity was highest at mid-altitude, showing a mix of low and high elevation elements, while beta diversity was notably influenced by altitude; however, diet composition varied with altitude without affecting its diversity.
  • - There was no clear genetic structure related to altitude among the host populations, and while free thyroxine levels increased with altitude, no specific bacteria correlated with hormone levels, although total thyroxine showed a positive connection to microbiome diversity.
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Immunotherapy has revolutionized cancer treatment in the last decade and has significantly improved patient survival. However, immunotherapy is associated with serious cardiac adverse events including myocarditis and conduction disturbances. In the literature, the mortality rate in patients with immunotherapy-associated myocarditis and complete AV block is reported to be approximately 60%.

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This study was aimed at evaluating the knowledge and attitudes of religious officials in Turkey about circumcision. Among the Imams, 96.7% (n = 234) were married, and 91.

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Magnetic nanoparticles (MNPs) are produced for both diagnosis and treatment due to their simultaneous availability in magnetic resonance imaging (MRI) and magnetic hyperthermia (MHT). Extensive investigations focus on developing MNPs for individual MHT or MRI applications, but the development of MNPs for theragnostic applications has received very little attention. In this study, through efficient examination of synthesis conditions such as metal precursors, reaction parameters, and solvent choices, we aimed to optimize MNP production for effective utilization for MHT and MRI simultaneously.

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  • The study focuses on elderly patients (65+) who experienced thoracic trauma, particularly highlighting their increased vulnerability to falls due to age-related health issues.
  • Among 261 patients analyzed, 52% had indoor trauma, and those with indoor accidents had a higher fall risk score compared to those with outdoor accidents.
  • The findings suggest a need for targeted measures to reduce trauma-related health problems in the geriatric population as it continues to grow, emphasizing both health risks and potential financial costs.
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This paper presents the development of a vital sign monitoring system designed specifically for professional athletes, with a focus on runners. The system aims to enhance athletic performance and mitigate health risks associated with intense training regimens. It comprises a wearable glove that monitors key physiological parameters such as heart rate, blood oxygen saturation (SpO2), body temperature, and gyroscope data used to calculate linear speed, among other relevant metrics.

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Elucidating organismal developmental processes requires a comprehensive understanding of cellular lineages in the spatial, temporal, and molecular domains. In this study, we introduce Zebrahub, a dynamic atlas of zebrafish embryonic development that integrates single-cell sequencing time course data with lineage reconstructions facilitated by light-sheet microscopy. This atlas offers high-resolution and in-depth molecular insights into zebrafish development, achieved through the sequencing of individual embryos across ten developmental stages, complemented by reconstructions of cellular trajectories.

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Background: Psoriasis is a chronic inflammatory disease often associated with serious cardiovascular comorbidities. The aim of this study was to investigate the systemic inflammatory burden in psoriasis by examining various inflammatory markers and to assess the relationship between these markers and the severity of the disease.

Methods: This retrospective study was conducted on medical records of patients who visited the dermatology outpatient clinic between 1 January 2016 and 31 December 2022.

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  • This study introduces a new breast cancer treatment that uses magnetic fields to heat nanoparticles for gene delivery and expression.
  • The researchers developed nanoparticles that can carry a gene encoding an anti-cancer protein while generating heat when exposed to an alternating current magnetic field.
  • Results showed that this method effectively increased cancer cell death while sparing non-cancerous cells, indicating a potential breakthrough in targeted cancer therapies.
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Background: It is noteworthy that there is an increase in medical lawsuits filed against nurses in Turkey and in the rest of the world. The purpose of this article is to examine nurses' criminal liability and senior nursing students' awareness of these responsibilities.

Methods: All senior students (n = 309) of the Faculty of Nursing who were studying in the 2020-2021 academic year of the university constituted the population of the research.

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  • Peripheral artery disease (PAD) is a serious health issue globally, causing significant health problems and increasing mortality, prompting the need for more effective management approaches.
  • A study analyzing data from the Unified National Electronic Healthcare System (2014-2021) revealed a rising trend in PAD incidences, with 19,507 hospitalizations, predominantly affecting older adults and linked to several comorbidities.
  • The findings indicate that conditions like heart failure and acute myocardial infarction enhance mortality risks in PAD patients, reinforcing the need for urgent interventions in Kazakhstan to address this growing health concern.
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  • This study aims to explore the relationship between specific liver function indices (albumin/bilirubin and AST/ALT ratios) and liver damage in pregnant women diagnosed with cholestasis, while also highlighting prevention strategies.* -
  • The research involved a retrospective analysis of 4019 pregnant women, from which 104 were diagnosed with gestational cholestasis, and 78 met the study's criteria to evaluate liver function indexes.* -
  • Findings indicated that women with cholestasis had higher levels of AST, ALT, albumin, and bilirubin compared to healthy controls, while the AST/ALT ratio was significantly lower in the cholestasis group, but no notable differences were found regarding the albumin/bilirubin index
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