Publications by authors named "Nilguen S Tekin"
Acidic marinades are commonly used to improve the quality meat products. However, no study has been performed to determine the effects of rhubarb juice as a marinating liquid on the quality parameters of chicken breast fillets. The aim of the present study was to identify the bioactive compounds (organic acids, polyphenols, and volatiles) in the juice of rhubarb and to determine the effect of rhubarb juice as a marinade on the microbiological (total viable count, psychrotrophs, lactic acid bacteria, sulfate-reducing anaerobes, and yeast-molds) and physico-chemical properties (drip loss, cooking loss, water holding capacity, pH, color, malondialdehyde, total volatile base nitrogen, and texture profiles), sensory attributes, and microbial safety (Escherichia coli O157:H7, Salmonella Typhimurium, and Listeria monocytogenes) of chicken breast fillets during a 15-day refrigerated storage.
View Article and Find Full Text PDFBackground: The Bari-SolidAct randomized controlled trial compared baricitinib with placebo in patients with severe COVID-19. A post hoc analysis revealed a higher incidence of serious adverse events (SAEs) among SARS-CoV-2-vaccinated participants who had received baricitinib. This sub-study aimed to investigate whether vaccination influences the safety profile of baricitinib in patients with severe COVID-19.
View Article and Find Full Text PDFObjective: The primary objective of this study was to identify the risk of metastasis to lymph nodes above the inferior mesenteric artery (IMA) in endometrioid-type endometrial cancer (EC) and the factors that influence metastasis.
Methods: The study included patients who had been operated on for endometrioid-type EC in three gynecological oncology centers between 2007 and 2023. The supramesenteric lymph node (SM-LN) is the region between the left renal vein and the IMA, whereas the inframesenteric lymph node (IM-LN) is the region between the IMA and the aortic bifurcation, as determined by the level of the IMA.
Article Synopsis
- - The study evaluated the efficacy of telehealth in conducting physical examinations (PE) for individuals with undiagnosed and rare disorders, comparing virtual assessments to in-person examinations.
- - Results showed high agreement in general appearance and craniofacial features between telehealth and in-person evaluations, with varying levels of agreement for neurological examination components.
- - Participants reported satisfaction with the telehealth experience, indicating that telehealth is a viable alternative for conducting physical examinations in cases of undiagnosed diseases.
Article Synopsis
- * Results indicated that higher goat's milk ratios led to improved antioxidant activity and stronger inhibition of certain enzymes, while sheep's milk increased the levels of specific volatile compounds and fatty acids.
- * The findings suggest that adjusting the milk type and ratio can enhance the health benefits and flavor profile of Lighvan cheese, potentially creating a functional white-brined cheese.
The involvement of lymph nodes critically affects patient outcomes in prostate cancer. While traditional risk models use factors like stage and PSA levels, the detection of lymph node involvement through modalities like PET targeting PSMA with Ga radiotracer plays a pivotal role in guiding treatments ranging from prostatectomy to pelvic radiotherapy. This study aims to create a deep learning model to predict lymph node involvement in intermediate to high-risk prostate cancer patients using Ga-PSMA PET/CT imagery, radiomics features, and various clinical parameters.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers collected 1,346 nasopharyngeal swab samples, isolating 879 high-quality genomes for analysis, focusing on clades, lineages, age-related associations, and mutations over a 10-month period.
- * Specific variants like B.1.1.7 (Alpha) and B.1.617.2 (Delta) were identified, along with unique mutations linked to the later Omicron variant, emphasizing the need for ongoing genetic monitoring to improve COVID-19 prevention strategies.
To determine the genetic causes of sensorineural hearing loss (SNHL) associated with inner ear anomalies, 11 unrelated Turkish individuals diagnosed with SNHL and an inner ear anomaly using temporal bone computed tomography and inner ear magnetic resonance imaging underwent exome or whole genome sequencing to identify underlying genetic defects. None of the individuals was diagnosed with a recognized syndrome. Four of the 11 probands were homozygous for variants, , , , and .
View Article and Find Full Text PDFBackground: The benefit of Inhaled nitric oxide (iNO) therapy in the setting of COVID-19-related ARDS is obscure. We performed a multicenter retrospective study to evaluate the impact of iNO on patients with COVID-19 who require respiratory support.
Methods: This retrospective multicenter study included COVID-19 patients enrolled in the SCCM VIRUS COVID-19 registry who were admitted to different Mayo Clinic sites between March 2020 and June 2022 and required high-flow nasal cannula (HFNC), non-invasive ventilation (NIV), or invasive mechanical ventilation (IMV).
Article Synopsis
- Pneumocystis jirovecii pneumonia (PJP) is an opportunistic infection that primarily affects immunocompromised individuals, presenting with symptoms like cough, fever, and especially aggressive courses in patients who have undergone allogeneic stem cell transplants.
- A case study details a 56-year-old male who, after an allogeneic stem cell transplant for acute myeloid leukemia, developed hypercalcemia and renal failure along with fatigue, leading to a confirmed diagnosis of PJP.
- Treatment included hydration, furosemide, and denosumab, and ultimately resolved both the hypercalcemia and the PJP infection with the patients’ follow-up showing improvement in symptoms.*
Introduction: This study investigated the feasibility of using the Roth score in the emergency setting to make hospitalization or discharge decisions for patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD).
Materials And Methods: This study was conducted prospectively between March 1, 2023 and January 1, 2024 and included 101 patients with Group E chronic obstructive pulmonary disease who were treated in the emergency department of a tertiary hospital. The patients were categorized into two groups: those who were hospitalized and those who were discharged.
Cystic echinococcosis (CE), caused by Echinococcus granulosus sensu lato (s.l.), represents one of the most significant zoonotic diseases globally, affecting both humans and animals.
View Article and Find Full Text PDFObjective: The infraorbital canal (IOC) houses critical structures like the infraorbital artery, vein, and nerve, and its atypical location within the maxillary sinus could pose risks during surgical procedures, making it crucial to understand its prevalence and distribution. The study aims to investigate the localization and frequency of the IOC within the maxillary sinus.
Methods: This retrospective study analyzed computed tomography (CT) images from 1000 randomly selected patients (500 males, 500 females) aged 18 to 65 years who underwent paranasal region imaging at Istanbul Medipol University Medipol Mega University Hospital between 2015 and 2020.
Article Synopsis
- Peroxisome biogenesis disorders (PBDs) include various diseases with diverse symptoms like developmental delays, hearing loss, and liver issues, linked to genetic mutations affecting peroxisome function.* -
- A patient was studied using whole-exome sequencing to identify genetic causes behind their clinical symptoms, which included developmental delays and organ enlargement, but no single-nucleotide mutations were found.* -
- However, a homozygous deletion in exon 4 of the gene was identified, affecting the protein's transmembrane domain, which is crucial for normal cellular processes and peroxisome function.*
Article Synopsis
- Human genetics research has made a lot of progress in finding out what causes diseases over the last ten years, thanks to sharing data and working together.
- The GENESIS platform helps scientists who may not know a lot about bioinformatics to analyze genetics data and discover new disease genes.
- With over 20,000 datasets from rare disease patients, GENESIS has contributed to discovering more than 100 new genes and helped solve many cases for patients with rare diseases.
Article Synopsis
- - The study investigated the protective effects of ozone on liver damage caused by sepsis in rats, using a model induced by cecal ligation and perforation (CLP).
- - Rats were divided into groups to compare the effects of ozone treatment before and after CLP, showing that pre-treatment significantly reduced liver injury markers and inflammatory responses.
- - Results indicated that ozone therapy led to lower levels of key liver injury markers and inflammatory cytokines while boosting antioxidant activity, suggesting its potential role in protecting the liver during sepsis.
Objectives: This study aimed to validate a Turkish version of the Composite Autonomic Symptom Score 31 (T-COMPASS 31) for assessing autonomic dysfunction.
Patients And Methods: The COMPASS 31 questionnaire was translated into Turkish following a rigorous protocol. Forty-five patients with autonomic dysfunction symptoms related to their primary disease and 45 healthy controls matched for age and sex participated in the study.
Objective: To objectively evaluate technical skill acquisition in hypospadias repair procedures during surgical training using noninvasive wearable sensor technology.
Methods: We combined subjective video evaluations with objective electromyography (EMG) measurements in a hands-on hypospadias training course. Surgeons wore wireless EMG and accelerometer sensors on their dominant hand while performing tasks on ex-vivo cadaveric calf penises.
Background: Pulmonary thromboembolism (PTE), often arising from deep vein thrombosis, remains a high-mortality condition despite diagnostic advancements. Prognostic models like Pulmonary Embolism Severity Index (PESI) and sPESI identify low-risk groups effectively. The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score, reflecting nutritional status and systemic inflammation, shows prognostic value in cancers and cardiovascular diseases.
View Article and Find Full Text PDFThe aim of this study is to examine the psychometric properties of the Turkish adaptation of the Morningness/Eveningness Scale (M/E Scale-Parent Report Form) family evaluation form for preschool children. The study sample consisted of 276 parents with children aged 4-6 years. The study calculated Cronbach's alpha internal consistency coefficient and corrected item-total correlations of the scale.
View Article and Find Full Text PDFWe aimed to explore the experiences, needs, and mental health impact of family members of healthcare workers (HCWs) before and during the COVID-19 pandemic. Eleven quantitative and nine qualitative studies were included in this review. Based on the narrative synthesis, we identified five outcomes: 'Mental health outcomes', 'Family relationships, 'Coping skills and resilience', 'Quality of life and social life', and 'Practical outcomes'.
View Article and Find Full Text PDFArticle Synopsis
- The study conducts a bibliometric analysis of articles published in the Journal of Craniofacial Surgery from 1990 to 2023, utilizing data from the Scopus database.
- It involves exporting detailed article information like citations, abstracts, and funding details, which is then analyzed using VOSviewer software.
- Findings show a total of 15,271 articles, with the U.S., Turkey, and China being the top contributors, highlighting the journal's significant and growing impact in craniofacial research globally.
Graphene nanoribbons (GNRs), categorized into zigzag and armchair types, hold significant promise in electronics due to their unique properties. In this study, optical properties of zigzag and armchair GNRs are investigated using density functional theory (DFT) in conjunction with Kubo-Greenwood formalism. Our findings reveal that optical characteristics of both GNR types can be extensively modulated through the application of a transverse electric field, e.
View Article and Find Full Text PDFObjectives: This study aims the analysis of the journal metrics of Journal of Craniofacial Surgery based on 2024 Journal Citation Reports (JCR) data.
Methods: In the Journal Citation Reports 2024, shared by Clarivate Analytics on June 20, 2024, the journal metrics of the Journal of Craniofacial Surgery were examined in detail.
Results: According to the reports published by Clarivate Analytics in 2024, the journal's impact factor in 2023 was determined as 1.
Article Synopsis
- - The study aimed to compare the fracture strength and modes of tooth post-cores made from modified polyetheretherketone (PEEK) using CAD-CAM technology against other custom post-cores like zirconia, metal, and glass fiber.
- - Researchers used sixty human mandibular first premolars, dividing them into six groups (each with 10 teeth) to test and measure fracture strength by applying force at a specific angle and analyzing the results statistically.
- - Results indicated a significant difference in fracture resistance; zirconia post-cores performed best compared to various PEEK-based groups, with zirconia showing a higher rate of repairable failure than others.