Long-term surgical outcomes of pediatric retinal detachment associated with primary congenital glaucoma.

Purpose: Primary congenital glaucoma (PCG) is an extremely rare disease with an incidence of one in 10,000 live births. Increasing axial length due to PCG predisposes to retinal thinning and retinal detachment (RD). The present study aims to determine the long-term surgical outcomes of pediatric RD associated with PCG.

Should we give priority to plasma exchange and hyperbaric oxygen treatment before deciding on amputation for severe crush injuries?

Background: The most common medical sequelae after earthquakes are crush injuries and syndromes that require urgent and well-organized care, which further complicates the approach in the face of overstretched resources. The 2023 Kahramanmaraş earthquake, with a magnitude of 7.7, was one of the largest disasters in Türkiye, affecting 11 cities with a population of about 13.

A global survey about undiagnosed rare diseases: perspectives, challenges, and solutions.

Background: Undiagnosed rare diseases (URDs) are a complex and multifaceted challenge, especially in low-and medium-income countries. They affect individuals with unique clinical features and lack a clear diagnostic label. Although the Undiagnosed Diseases Network International (UDNI) definition of URDs is not universally accepted, it is widely recognized.

Assessing the prognostic value of HALP score in peripheral artery disease: Correlation with lesion severity and long-term mortality.

IntroductionPeripheral artery disease (PAD) poses a growing clinical challenge due to an aging population, despite advances in treatment methods. Various scoring systems have emerged to predict high-risk patients, including the HALP (hemoglobin, albumin, lymphocyte, and platelet) score, known for predicting prognosis in cancers and stroke. This study assesses the HALP score's relation to lesion severity and long-term mortality in PAD patients.

AI-assisted decision-making in mild traumatic brain injury.

Objective: This study evaluates the potential use of ChatGPT in aiding clinical decision-making for patients with mild traumatic brain injury (TBI) by assessing the quality of responses it generates for clinical care.

Methods: Seventeen mild TBI case scenarios were selected from PubMed Central, and each case was analyzed by GPT-4 (March 21, 2024, version) between April 11 and April 20, 2024. Responses were evaluated by four emergency medicine specialists, who rated the ease of understanding, scientific adequacy, and satisfaction with each response using a 7-point Likert scale.

Diastolic dysfunction in Behçet's disease and its relationship with clinical manifestations of the disease: A case-control study.

Objectives: The study aimed to evaluate the frequency of diastolic dysfunction (DD) in patients with Behçet's disease (BD) and its relationship with clinical manifestations.

Patients And Methods: Seventy patients (35 females, 35 males; mean age: 39.3±11.

Multimodal Imaging for Evaluation and Quantification of Atrophy Progression in Extensive Macular Atrophy with Pseudodrusen.

Aim: To present the atrophy progression rate with fundus autofluorescence (FAF) and optical coherence tomography (OCT) findings in patients with extensive macular atrophy with a pseudodrusen-like appearance.

Methods: Eight patients who were followed up with the diagnosis of diffuse macular atrophy accompanied by pseudodrusen were included. Medical records, FAF, and OCT images at consecutive follow-ups were reviewed.

Pharmacovigilance analysis of immune checkpoint inhibitor-related reproductive adverse effects based on the FDA adverse event reporting system.

This study aims to investigate the adverse effects of immune checkpoint inhibitors (ICIs) on the female and male reproductive systems. In the FDA Adverse Event Reporting System (FAERS) database, adverse reactions under the "Reproductive system and breast disorders" category in the System Organ Classes were included, covering a period from January 1, 2015, to June 30, 2023. We identified 133,512 patients treated with ICIs.

Characterization of Pseudomonas Phage MME: A Novel Tool for Combatting Multidrug-Resistant Pseudomonas aeruginosa and Disinfection.

Aim: Combatting Pseudomonas aeruginosa, known for its robust biofilm formation, presents significant challenges in healthcare, food, and industry. Phages offer promising alternatives against this resilient pathogen. We aim to demonstrate their viability as alternative therapeutic and decontamination options.

Overuse of Computed Tomography Pulmonary Angiography in the Diagnosis of Pulmonary Thromboembolism "Real-Life Data".

Purpose: Pulmonary thromboembolism (PTE) is a common cause of cardiovascular mortality with an increasing incidence rate. Scoring patients with suspected pulmonary thromboembolism according to their symptoms, findings, and risk factors is useful for empirical diagnosis and management. The combination of D-dimer and clinical scoring allows the diagnosis to be excluded in approximately 30% of patients with suspected PTE without the need for imaging methods.

Clinical management of three JMML siblings with germline CBL variation.

Germline pathogenic variants (PVs) in CBL are found in 15 % of juvenile myelomonocytic leukemia (JMML) cases. Here we report three siblings with CBL(NM_005188):c.1111T>C variation presenting a heterogenous JMML clinic and outcome.

Impact of Deep Cryogenic Treatment on X210CrW12 Steel's Wear Behavior and Microstructural Characteristics.

In this work, the microstructure, hardness, tensile and yield strength, and wear resistance of X210CrW12 steel are examined in relation to the impacts of deep cryogenic treatment. In order to achieve this, deep cryogenic treatment at -180 °C was applied to X210CrW12 steel samples for 12, 18, 24, and 36 h following quenching. Following the cryogenic treatments, a tempering heat treatment was applied to the samples at 300 °C for two hours.

A precise targeting of Staphylococcus aureus with phage RBP-decorated antibiotic-loaded nanoparticles.

Resistant strains of Staphylococcus aureus, which have emerged due to the excessive and indiscriminate use of antibiotics, have become one of the most significant causes of hospital-acquired infections, highlighting the necessity for specific and effective alternative methods in combating them. Leveraging the therapeutic potential of bacteriophage receptor binding protein (RBP), which occurs unique and irreversible binding of its host, in recognizing bacteria renders them valuable components in the development of targeted nanoparticle-based drug delivery systems, and offers promising approach to combat antibiotic resistance. In this study, synthesis and characterization of rifampicin-loaded PLGA nanoparticle (RIF-NP) were conducted and for selective targeting of S.

National eHealth strategies: a comparative study of nine OECD health systems.

Background: The development of effective eHealth strategies is critical to enhancing healthcare systems' efficiency and outcomes. However, there is limited comparative analysis of eHealth strategies across health systems, particularly in terms of their vision, objectives, implementation methods, and follow-up processes. This study compares the eHealth strategies of nine health systems, focusing on three key dimensions: vision and objectives, means to achieve objectives, and structures for follow-up.

Phage-inspired targeting of antibiotic-loaded polymeric micelles for enhanced therapeutic efficacy against monomicrobial sepsis.

The rapid increase in bacterial resistance to existing treatments underscores the critical need for novel therapeutic strategies. Here, an innovative approach using targeted nanocarrier systems that mimic phage-bacteria interactions through phage receptor binding protein (Gp45 from the ϕ11 lysogenic phage) or derived peptides (P1, P2, P3, P4, P5), are introduced. These nanodrugs, exhibited receptor-ligand specificity and strong binding affinity, for the first time, were employed for the precise delivery and targeting of antibiotics within living organisms.

Effects of Yoga on Pulmonary Parameters, Posture, Body Awareness, and Quality of Life Among Smokers.

Background: Smoking is considered one of the most important public health problems globally, and smokers have reduced lung functions, poor posture, and lower quality of life.

Primary Study Objective: To evaluate the effects of yoga practice among chronic smokers.

Methods: This case-control study included 28 participants with a power independent of 0.

Investigation of Neuronal-Astroglial Injury Proteins and MMP-9 Serum Levels in Autism Spectrum Disorder and Their Relationship With Autistic Regression.

Objective: This study compared serum levels of S100B, GFAP, UCHL-1, NF-H and MMP-9 between children with Autism Spectrum Disorder (ASD) and controls, focusing on their association with regression in ASD. We hypothesized that neuroinflammation and neuronal/astroglial damage markers would be higher in the ASD group than in controls and even more elevated in the regressive ASD subgroup compared to the non-regressive subgroup.

Methods: The study included 50 children with ASD (ages 4-10) and 30 healthy children.

Global Longitudinal Strain score predicts subclinical cardiac involvement of multiple sclerosis patients.

Background: People with multiple sclerosis (MS) have a higher risk of cardiovascular disease than the general population, but the data are limited. Evaluation with strain echocardiography, a new echocardiographic method, can provide more objective data to evaluate global and segmental left ventricular systolic functions. Left ventricular Global Longitudinal Strain (GLS) may be useful in demonstrating subclinical myocardial dysfunction in MS, therefore we planned such a study.

Evaluation and Effect of Transfusion on Respiratory Functions in Patients with β-Thalassemia Major.

The lung is one of the organs that can be damaged in patients with thalassemia major (TM). In this study, we aimed to evaluate the pattern of lung impairment using various pulmonary tests and the effects of transfusion on pulmonary functions in patients with TM. The study was performed on patients 9-21 years of age prospectively.

Effects of FD777 and Extract on Performance, Immunity, Gastrointestinal System Microbiome, and Profitability in Holstein Calves.

This study was performed to determine the effects of dietary supplementation of FD777 (BA) and extract (MCE) on the performance, morbidity and mortality rates, body measurements, immunity, rumen parameters, antioxidant parameters, microbiome level, and profitability of calves during the pre-weaning period. In the study, 51 calves were divided into three groups as one control and two treatment groups considering their age (1 day old), gender (nine females and eight males in each group), and birth weight (37.7 ± 0.

Phenotypic diversity in NAXE mutations.

Background/aim: NAD(P)HX epimerase (NAXE) gene mutations have been associated with early onset progressive encephalopathy. We present three patients with NAXE gene mutations and different initial manifestations.

Cases: Patient(P)1 was a 30 month-old boy whose neurological regression started after an infection and progressed, ultimately leading to death one year later.

Management of rare and undiagnosed diseases: insights from researchers and healthcare professionals in Türkiye.

Introduction: Diagnosis, treatment and management of rare diseases (RD) pose unique challenges due to their complex nature, significantly impacting the daily experiences of researchers and healthcare professionals working in this field. Despite increasing awareness and progress in the field of RD worldwide in recent years, a significant gap remains in our understanding of the specific barriers that these professionals face in their work with RD. This study provides a detailed survey analysis that sheds light on the challenges that researchers and healthcare professionals face in diagnosing, treating, managing and conducting research on RD.

Genomics of rare diseases in the Greater Middle East.

The Greater Middle East (GME) represents a concentrated region of unparalleled genetic diversity, characterized by an abundance of distinct alleles, founder mutations and extensive autozygosity driven by high consanguinity rates. These genetic hallmarks present a unique, yet vastly untapped resource for genomic research on Mendelian diseases. Despite this immense potential, the GME continues to face substantial challenges in comprehensive data collection and analysis.

Increased epicardial adipose tissue volume may adversely affect outcomes in patients undergoing transcatheter aortic valve implantation.

Introduction: Epicardial adipose tissue (EAT) influences the development of cardiovascular diseases through the secretion of inflammatory cytokines. Transcatheter aortic valve implantation (TAVI) is one of the most commonly used methods for treating severe aortic stenosis in adults.

Aim: Given the role of inflammatory cytokines in the progression of aortic stenosis, we investigated the impact of EAT on the outcomes of patients undergoing TAVI.

Hidradenitis Suppurativa Treatment During Pregnancy and Lactation: Navigating Challenges.

Hidradenitis suppurativa (HS), or acne inversa, is a chronic inflammatory skin condition primarily affecting skin folds such as the axilla, groins, and the inframammary, perineal, and perianal regions. It is characterized by painful abscesses, sinus tracts, and scarring. Predominantly affecting young adults, particularly females, HS often emerges during reproductive age, and flares are widely reported during pregnancy and postpartum, underscoring the need to consider management strategies tailored to pregnant or lactating individuals.