Derivation and validation of a simple prognostic risk score to predict short-term mortality in acute cardiogenic pulmonary edema: SABIHA Score.

Objective: In the context of acute cardiogenic pulmonary edema (ACPE), a frequently encountered medical emergency associated with high early mortality rates, there is a need to predict short-term outcomes for risk stratification.Our aim was to derive and validate a model, a simple clinical scoring system using baseline vital signs, clinical and presenting characteristics, and readily available laboratory tests, that allows accurate prediction of short-term mortality in individuals experiencing ACPE.

Methods: This retrospective cohort study included 1088 patients with ACPE from six health centers.

Investigation of the efficiency of different reprocessing methods on disposable laryngeal masks contaminated with HBV DNA.

Background: The use of laryngeal masks (LM) has increased widely today, both in anesthesia and in emergency cases. LM are available as reusable and disposable. Although reuse of disposable LM is not recommended, they are reused again after decontamination with different methods in anesthesia units in some countries.

Topsy-Turvy Heart: Exceedingly Rare Congenital Rotational Heart Disease With Large Aorticopulmonary Window and Severe Tracheobroncial Malacia.

Left images: Top: (A) Echocardiography shows a dilated pulmonary artery, large aortopulmonary window (dotted line), and abnormally positioned aortic arch. (B) MIP image reveals superior RV, inferior LV, and elongated arch vessels (arrows). Bottom: MinIP shows a thin left main bronchus and non-aerated RML (asterisk).

[Multicentric Screening of Local Antibiotic Resistance in Uncomplicated Urinary System Infections: 1850 Patients from 37 Centers].

This study was aimed to identify the most frequently observed pathogens in uncomplicated urinary tract infections from outpatient urinary isolates obtained across seven different geographical regions in Türkiye and to determine whether the antibiotic resistance rates of these pathogens differ significantly between these regions. The study included patients aged 18 to 65 years who were diagnosed with uncomplicated urinary tract infections and had positive urine cultures from March 2021 to August 2022, across 37 different centers in Türkiye. The participating centers were selected based on their use of the disk diffusion method, in line with the European Committee on Antimicrobial Susceptibility Testing (EUCAST) guidelines, to ensure standardization of urine culture data.

Evaluation of the color stability of resin composites subjected to artificial aging procedures: immersion in different solutions, brushing, and thermal cycling.

The aim of this in vitro study was to evaluate the color change of resin composites with different filler contents subjected to immersion in different solutions, brushing, and thermal aging procedures. A total of 320 samples were prepared using 4 different flowable and 4 different conventional resin composites (n = 40). The samples were separated into 4 subgroups according to the solution to be used (wine, coffee, tea, or distilled water) and then immersed in the solutions for 12 days.

Can trauma scores predict the length of hospital stay of patients with fractures after earthquake-related blunt injury?

Objective: The number of patients during disastrous conditions was high, and triage is essential. In chaotic circumstances, orthopedic surgeons can also struggle with patient selection, not only for surgical selection but also for the necessity of hospitalization. So, the performance of the Injury Severity Score, New Injury Severity Score, and Trauma and Injury Severity Score was compared in victims who were struck under the wreckage and had fractures due to the Kahramanmaras Earthquake.

Carbon Monoxide Intoxication Leading to Crush Syndrome and Acute Renal Failure: A Case Report.

Carbon monoxide (CO) poisoning is a common occurrence, typically resulting from exposure to CO emissions in enclosed spaces. CO is a colorless, odorless, and tasteless gas. In this case report, we present a 52-year-old male patient who developed crush syndrome and acute kidney injury following carbon monoxide (CO) intoxication.

Improving subject transfer in EEG classification with divergence estimation.

. Classification models for electroencephalogram (EEG) data show a large decrease in performance when evaluated on unseen test subjects. We improve performance using new regularization techniques during model training.

The Association of Electrical Risk Score with Prognosis in Patients with Non-ST Elevation Myocardial Infarction Undergoing Coronary Angiography.

Background: Acute coronary syndromes are the leading cause of mortality worldwide. Electrical risk score (ERS) is a novel electrocardiographic risk scoring system. The prognostic importance of ERS in non-ST elevation myocardial infarction (NSTEMI) patients is unknown.

Supporting Evidence in Phase 2 Cancer Trial Protocols: A Content Analysis.

Background: Phase 2 trials are instrumental for designing definitive efficacy trials or attaining accelerated approval. However, high attrition of drug candidates in phase 2 raises questions about their supporting evidence.

Methods: We developed a typology of supporting evidence for phase 2 cancer trials.

Generative adversarial networks to create synthetic motion capture datasets including subject and gait characteristics.

Resource-intensive motion capture (mocap) systems challenge predictive deep learning applications, requiring large and diverse datasets. We tackled this by modifying generative adversarial networks (GANs) into conditional GANs (cGANs) that can generate diverse mocap data, including 15 marker trajectories, lower limb joint angles, and 3D ground reaction forces (GRFs), based on specified subject and gait characteristics. The cGAN comprised 1) an encoder compressing mocap data to a latent vector, 2) a decoder reconstructing the mocap data from the latent vector with specific conditions and 3) a discriminator distinguishing random vectors with conditions from encoded latent vectors with conditions.

Improving the Bioactivity and Antibiofilm Properties of Metallic Implant Materials via Controlled Surface Microdeformation.

Although metallic implants provide most of the required properties for bone-related applications, especially orthopedic implants, insufficient osseointegration, which may lead to loosening of the implant or prolonged healing time, is still an issue to be resolved. Osseointegration can be improved via application of various surface treatments on the metal surface. The current study focuses on a novel surface microdeformation method, which enables the formation of controlled surface patterns of various parameters.

Human Breast Milk Exosomes: Affecting Factors, Their Possible Health Outcomes, and Future Directions in Dietetics.

Human breast milk is a complex biological fluid containing multifaceted biological compounds that boost immune and metabolic system development that support the short- and long-term health of newborns. Recent literature suggests that human breast milk is a substantial source of nutrients, bioactive molecules, and exosomes. This review examines the factors influencing exosomes noted in human milk and the impacts of exosomes on infant health.

Synthesis of N-substituted 4-phenyl-2-aminothiazole derivatives and investigation of their inhibition properties against hCA I, II, and AChE enzymes.

In this study, thiazole derivatives containing sulphonamide, amide, and phenyl amino groups were synthesized to protect the free amino groups of 5-methyl-4-phenyl-2-aminothiazole and 4-phenyl-2-aminothiazole. Halogenated reactions of N-protected thiazole derivatives have been investigated. LCMS, FT-IR, H NMR, and C NMR spectroscopy techniques were used to elucidate the structures of the synthesized compounds.

The relationship between changes in peritoneal permeability with CA-125 and HIF-1α.

Background: Peritoneal fibrosis (PF) is a major, persistent complication of prolonged peritoneal dialysis that eventually leads to peritoneal ultrafiltration failure and termination of peritoneal dialysis. Prolonged exposure to high glucose concentrations, degradation products, uremic toxins, and episodes of peritonitis can cause some changes in the peritoneal membrane, resulting in intraperitoneal inflammation and PF, leading to failure of ultrafiltration and dialysis. CA-125 can be used as a biomarker of peritoneal mesothelial cell count in the peritoneal dialysate and for monitoring cell count in PD patients.

The Effect of CD31 on Coronary Collateral Development.

Background: Coronary collaterals are the feeding bridges between the main epicardial arteries, and research has shown that this collateral development plays a crucial role in myocardial performance, especially in patients with coronary artery disease. However, the evolution of these collaterals has not been fully explained.

Objective: In this study, we aimed to reveal the effect of CD31 on coronary collateral development.

How reliable is the artificial intelligence product large language model ChatGPT in orthodontics?

Objectives: To evaluate the reliability of information produced by the artificial intelligence-based program ChatGPT in terms of accuracy and relevance, as assessed by orthodontists, dental students, and individuals seeking orthodontic treatment.

Materials And Methods: Frequently asked and curious questions in four basic areas related to orthodontics were prepared and asked in ChatGPT (Version 4.0), and answers were evaluated by three different groups (senior dental students, individuals seeking orthodontic treatment, orthodontists).