The effect of fatigue on seafarers' ship-boarding process: jet lag disorder.

In parallel with the rising world population, consumption is increasing. Seafarers work intensively for the continuity of consumption. Vessel crew work under contract for specific periods.

The Changes in ICD-11 Related to Sexual Health and Dysfunction and Their Implication for Clinical Practice.

The classification of sexual health-related conditions was reformulated in 11th revision of International Classification of Diseases (ICD-11) following current evidence, best practice, and taking human rights into consideration, which is expected to reflect and provide guidance for more integrative clinical approaches. Overcoming the artificial, yet historical, distinction between "organic" and "non-organic" conditions, sexual dysfunctions classified in the "Mental and Behavioral Disorders" and "Disorders of Genitourinary System" in ICD-10 were listed in a new chapter called "Conditions Related to Sexual Health." In practice, this approach has been consistently recommended.

Do the ınflammatory markers have a prognostic role in an elderly patient population diagnosed with non-muscle ınvasive bladder cancer?

Objective: To evaluate whether the systemic immune-inflammation index (SII), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and De-Ritis ratio (DRR) are determinants of progression-free survival (PFS), recurrence-free survival (RFS) and overall survival (OS) in patients aged ≥ 70 years diagnosed with non-muscle invasive bladder cancer (NMIBC).

Method: The study included 173 elderly patients diagnosed with NMIBC between January 2015 and March 2022. The clinical and pathological data of the patients were examined.

Olive oil and castor oil-based self-nanoemulsifying drug delivery system of flurbiprofen can relieve peripheral pain and inflammation through reduction of oxidative stress and inflammatory biomarkers: a comprehensive formulation and pharmacological insights.

Flurbiprofen (FBP) is poorly water-soluble BCS class II drug with anti-inflammatory and analgesic effects, used to treat arthritis and degenerative joint diseases. This study was aimed to develop SNEDDS loaded with FBP. Six SNEDDS using two oils olive oil (F, F, F) and castor oil (F, F, F) with three different Smix ratios consisting of Tween 20 and PEG 400 (1:1, 1:2, 2:1) were prepared and characterized.

Artificial Intelligence in IVF Laboratories: Elevating Outcomes Through Precision and Efficiency.

Incorporating artificial intelligence (AI) into in vitro fertilization (IVF) laboratories signifies a significant advancement in reproductive medicine. AI technologies, such as neural networks, deep learning, and machine learning, promise to enhance quality control (QC) and quality assurance (QA) through increased accuracy, consistency, and operational efficiency. This comprehensive review examines the effects of AI on IVF laboratories, focusing on its role in automating processes such as embryo and sperm selection, optimizing clinical outcomes, and reducing human error.

A Comparative Study on the Clinical Outcomes of Bipolar Radiofrequency Thermotherapy Versus Transurethral Resection of the Prostate in Storage Symptoms Associated With Benign Prostatic Obstruction.

Purpose: The aim of the study was to compare the results of radiofrequency (RF) thermotherapy and transurethral resection of the prostate (TURP) in patients who required benign prostatic obstruction (BPO) surgery and had storage symptoms.

Methods: The results of patients who had undergone TURP and RF thermotherapy procedures between December 2019 and 2022 were compared before and after the procedure. Patients' International Prostate Symptom Scores, maximum flow rate (Qmax), postvoiding residues, and overactive bladder validated 8 scores (OAB-V8) at 3 and 6 months were analyzed.

Overcoming CD226-related immune evasion in acute myeloid leukemia with CD38 CAR-engineered NK cells.

CD226 plays a vital role in natural killer (NK) cell cytotoxicity, interacting with its ligands CD112 and CD155 to initiate immune synapse formation, primarily through leukocyte function-associated-1 (LFA-1). Our study examined the role of CD226 in NK cell surveillance of acute myeloid leukemia (AML). NK cells in patients with AML had lower expression of CD226.

The impact of tobacco consumption on household catastrophic health expenditure in Türkiye.

Background: Understanding the financial burden of smoking on households is crucial for developing effective strategies and policies to reduce smoking and mitigate its impact on household health.

Aim: To investigate the relationship between smoking and catastrophic health expenditure in Türkiye.

Methods: This cross-sectional study used microdata from household budget surveys conducted by the Turkish Statistical Institute in 2015 and 2019.

DNA protection, molecular docking, molecular dynamic, enzyme inhibition, and kinetics studies of apigenin isolated from Hedge & Lamond by bioactivity-guided fractionation.

Plant-derived bioactive substances have demonstrated significant qualities that suggest they may be crucial in preventing various chronic diseases. Flavonoids, which include apigenin, are the biggest group of polyphenols. In our study, we aimed to obtain the methanol-chloroform (1:1) extract from the aerial parts of Hedge & Lamond and purify the apigenin using bioactivity-guided isolation to separate the active fraction.

Comparison of the Effects of Ultrasound-Guided Subacromial Injection Versus Subacromial Injection and Suprascapular Nerve Block on Pain, Function, and Sleep Quality in Rotator Cuff Lesions.

Rotator cuff lesions are common causes of shoulder pain. When not treated effectively, the functional loss associated with pain affects the quality of life and brings about psychosocial issues. In this study, prospective observational comparison of the effects of ultrasonography (USG) guided subacromial injection (SAI) versus subacromial injection combined with suprascapular nerve block (SSNB) on pain, functionality and sleep quality in the treatment of shoulder pain unresponsive to conservative treatments due to rotator cuff lesions is made.

Another lesson from the earthquake: Transdermal fentanyl dependence in two child victims.

Thousands died in the Kahramanmaraş-centered earthquake in February 2023, and even more were injured. Some were administered transdermal fentanyl patches (TFPs) due to severe pain. Two pediatric patients, both severely injured victims of the earthquake, developed dependence on TFPs and experienced difficulties during the cessation of fentanyl treatment.

Affective modulation of emotional reactivity in euthymic patients with bipolar disorder.

Background: Affective modulation of startle reflex (AMSR) is a widely used experimental tool for assessing emotional reactivity. Previous research has shown inconsistent findings of emotional reactivity in amplitude in bipolar patients (BP). This study examined emotional reactivity (ER) in euthymic BP compared to healthy controls using both subjective and objective measures.

Psychological and Pain Factors in Microsurgical Testicular Sperm Extraction (Micro-TESE) for Non-Obstructive Azoospermia: A Comparative Study of Successful and Unsuccessful Cases.

Purpose: This study aimed to assess postoperative pain, depression, and anxiety levels in infertile men who underwent microsurgical testicular sperm extraction (micro-TESE) for non-obstructive azoospermia (NOA) and compare results between patients with successful and unsuccessful sperm retrieval.

Material And Methods: A total of 105 NOA patients participated, completing preoperative Beck Depression Inventory (BDI) and Situational and Transient Anxiety Inventory (SAI and TAI) questionnaires. Postoperatively, Visual Analog Scale (VAS) scores were recorded.

Spiritual needs of family caregivers in palliative care.

Objective: The primary aim of this study is to elucidate the spiritual needs encountered by family members who intricately engage in the progression of illness within the palliative care framework, thus assuming the paramount responsibility of caregiving.

Methods: This study was approved by the Institutional Review Board and Ethics Committee of the University of Health Sciences İzmir Tepecik Training and Research Hospital (17/01/2022-2022/01-16). The research was designed as a prospective study.

Unlocking Precision Enhancing Prostate Cancer Detection and Reducing Unnecessary Biopsies with Combined Prostate-Specific Antigen Density and PI-RADS Score.

Objective: To determine clinically significant prostate cancer (csPCa) detection rate by combining the prostate-specific antigen density (PSAD) and prostate imaging-reporting and data system (PI-RADS) scores.

Study Design: Descriptive study. Place and Duration of the Study: Department of Urology, University of Health Sciences, Ankara Oncology Training and Research Hospital, from January 2018 to April 2023.

Sustainable Thermoplastic Material Selection for Hybrid Vehicle Battery Packs in the Automotive Industry: A Comparative Multi-Criteria Decision-Making Approach.

This research study employs a comparative Multi-Criteria Decision-Making (MCDM) approach to select optimal thermoplastic materials for hybrid vehicle battery packs in the automotive industry, addressing the challenges posed by high-temperature environments. Through a detailed evaluation of materials based on criteria such as thermal stability, mechanical strength, chemical resistance, and environmental impact, the research identifies materials that enhance battery efficiency, longevity, and vehicle performance. Utilizing SWARA-ARAS, SWARA-EDAS, and SWARA-TOPSIS methods, the study systematically assesses and ranks various polymers, providing recommendations that prioritize safety, performance, and sustainability.

The Impact of Chest Binding on Pulmonary Functions of Trans and Gender Diverse Youth.

Purpose: There is a scarcity of information regarding the health consequences of chest binding and its effects on pulmonary functions (PFs). This study aimed to evaluate binding practices, physical outcomes, and effects on PFs of trans or gender diverse (TGD) youth who bind.

Methods: The TGD and control groups underwent pulmonary function tests (PFTs), with the TGD group undergoing testing both with their binder and after removal.

Screening depression among university students utilizing GHQ-12 and machine learning.

The escalating incidence of depression has brought attention to the increasing concern regarding the mental well-being of university students in the current academic environment. Given the increasing mental health challenges faced by students, there is a critical need for efficient, scalable, and accurate screening methods. This study aims to address the issue by using the General Health Questionnaire-12 (GHQ-12), a well recognized tool for evaluating psychological discomfort, in combination with machine learning (ML) techniques.

Effects of music on perioperative anxiety in patients undergoing cesarean section - A randomised prospective controlled study.

Premedication with sedative drugs is one of the most preferred methods to reduce anxiety. Due to concerns about maternal and fetal side effects, their use in obstetric anesthesia is not preferred. The primary aim of the authors of this study is to investigate the effect of music on perioperative anxiety in pregnant.

BATF is a major driver of NK cell epigenetic reprogramming and dysfunction in AML.

Myelodysplastic syndrome and acute myeloid leukemia (AML) belong to a continuous disease spectrum of myeloid malignancies with poor prognosis in the relapsed/refractory setting necessitating novel therapies. Natural killer (NK) cells from patients with myeloid malignancies display global dysfunction with impaired killing capacity, altered metabolism, and an exhausted phenotype at the single-cell transcriptomic and proteomic levels. In this study, we identified that this dysfunction was mediated through a cross-talk between NK cells and myeloid blasts necessitating cell-cell contact.

Enhancing outcomes in IVF laboratories: navigating the human element through leadership and emotional intelligence.

Purpose: We analyze the psychological and interpersonal aspects of in vitro fertilization (IVF) laboratory operations, highlighting how human factors such as leadership style, emotional intelligence (EI), and team dynamics influence the effectiveness of IVF treatments. We also examine the role of personality dynamics in team functioning and the adverse effects of toxic behaviors on laboratory performance and morale.

Methods: The manuscript comprehensively reviews contemporary literature about leadership styles, EI, and team dynamics.