Publications by authors named "Nileshkumar Shah"
Byssinosis is a disabling occupational lung disease caused by cotton dust. It is a well-known occupational respiratory disease in cotton industry workers caused by cotton dust pollution. Many studies have been documented the effects of cotton dust on pulmonary function among workers employed in cotton-spinning mills.
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- The EDA+ splice variant of fibronectin is crucial in kidney fibrosis, and this study explores how it's produced in human proximal tubule epithelial cells (PTECs) in response to TGFβ1.
- The production of EDA+Fn was examined using various techniques, revealing that TGFβ1 stimulates its production through the PI3 kinase-AKT signaling pathway and the splicing regulatory protein SRp40.
- The research shows that inhibiting SRp40 can affect fibronectin splicing, suggesting that targeting this process might be a potential strategy to reduce kidney fibrosis.